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Sperm Chromatin

Biological and Clinical Applications in Male Infertility and Assisted Reproduction

Specificaties
Paperback, blz. | Engels
Springer New York | e druk, 2016
ISBN13: 9781493951321
Rubricering
Juridisch :
Springer New York e druk, 2016 9781493951321
Verwachte levertijd ongeveer 9 werkdagen
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Samenvatting

Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage. The work covers the fundamental principles of sperm chromatin architecture and function, the proposed modes of DNA damage and repair, the tests of sperm DNA damage, the clinical aspects of DNA damage and the impact of DNA damage on reproductive outcome. Unlike any other title on the topic, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction is an invaluable addition to the literature and will serve as an indispensable resource for basic scientists with an interest in sperm biology and for urologists, gynecologists, reproductive endocrinologists, and embryologists working in the field of infertility.

Specificaties

ISBN13:9781493951321
Taal:Engels
Bindwijze:paperback
Uitgever:Springer New York

Inhoudsopgave

<p>I. Human Sperm Chromatin: Structure and Function</p><p>1. Sperm Chromatin: An Overview <br>Rodney Balhorn</p><p>2. Spermatogenesis: An Overview  <br>Rakesh Sharma and Ashok Agarwal</p><p>3. Sperm Nucleoproteins<br>Rafael Oliva and Judit Castillo</p><p>4. The Relationship Between Chromatin Structure and DNA Damage in Mammalian Spermatozoa<br>Kenneth Dominguez, Chris D. R. Arca, and W. Steven Ward</p><p>5. Chromosome Positioning in Spermatozoa<br>Andrei Zalensky, Olga Mudrak, and Irina Zalenskaya </p><p>6. Sperm Mitochondrial DNA<br>Justin C. St. John and Bianca St. John</p><p>7. The Sperm Epigenome<br>Donovan Chan and Jacquetta Trasler </p><p>8. RNA Expression in Germ Cells During Spermatogenesis (Germ Cell Transcriptome)  <br>Tin-Lap Lee, Albert Hoi-Hung Cheung, Owen M. Rennert, and Wai-Yee Chan</p><p>II. Laboratory Evaluation of Sperm Chromatin</p><p>9. Sperm Chromatin Structure Assay (SCSA®): 30 Years’ Experience with the SCSA®<br>Donald P. Evenson </p><p>10. Sperm Chromatin Dispersion Test: Technical Aspects and Clinical Applications<br>Jaime Gosálvez, Carmen López-Fernández, and José Luís Fernández </p><p>11. Basic and Clinical Aspects of the Sperm Chromomycin A3 Assay <br>Giancarlo Manicardi, Davide Bizzaro, and Denny Sakkas</p><p>12. Cytochemical Tests for Sperm Chromatin Maturity<br>Igor Tsarev and Juris Erenpreiss </p><p>13. Acridine Orange Test for Assessment of Human Sperm DNA Integrity<br>Alex C. Varghese, C. Fischer–Hammadeh, and M. E. Hammadeh </p><p>14. Laboratory Evaluation of Sperm Chromatin: TUNEL Assay<br>Rakesh Sharma and Ashok Agarwal</p><p>15. The Basic and Clinical Aspects of the Sperm Comet Assay<br>Luke Simon and Sheena E. M. Lewis</p><p>16. Assays Used in the Study of Sperm Nuclear Proteins<br>Timothy G. Jenkins, Benjamin R. Emery, and Douglas T. Carrell</p><p>17. Sperm Epigenetic Profile<br>Cristina Joana Marques, Alberto Barros, and Mário Sousa</p><p>18. Clinical Significance of Sperm RNA<br>Jean-Pierre Dadoune, Isabelle Galeraud-Denis, and Serge Carreau </p><p>III. Biological and Clinical Determinants of Sperm Chromatin Damage</p><p>19. Role of Oxidative Stress in the Etiology of Sperm DNA Damage<br>R. John Aitken and Geoffry N. De Iuliis</p><p>20. Abortive Apoptosis and Sperm Chromatin Damage<br>Hasan M. El-Fakahany and Denny Sakkas</p><p>21. Spermiogenesis in Sperm Genetic Integrity<br>Marie-Chantal Grégoire, Frédéric Leduc, and Guylain Boissonneault</p><p>22. Male Subfertility and Sperm Chromatin Damage<br>Mona Bungum, Aleksander Giwercman, and Marcello Spanò </p><p>23. Aging and Sperm DNA Damage<br>Fábio F. Pasqualotto and Eleonora B. Pasqualotto</p><p>24. Cancer in Males: Implications for Sperm Quality, Fertility, and Progeny Outcome<br>Peter Chan and Bernard Robaire</p><p>25. Sperm Chromatin and Environmental Factors<br>Aleksander Giwercman</p><p>26. Effects of Male Accessory Gland Infection on Sperm Parameters<br>Aldo E. Calogero, Sandro La Vignera, Rosita A. Condorelli, Rosario D’Agata, and Enzo Vicari</p><p>IV. Sperm Chromatin and Assisted Reproductive Technology Outcomes</p><p>27. The Impact of Sperm Processing and Cryopreservation on Sperm DNA Integrity<br>Dan Yu, Luke Simon, and Sheena E. M. Lewis</p><p>28. Structure of Chromatin in Human Sperm Bound to Hyaluronic Acid: The Benefits of PICSI Dish Mediated Sperm Selection<br>Leyla Sati and Gabor Huszar</p><p>29. Electrophoretic Sperm Separation<br>Steven Fleming and R. John Aitken</p><p>30. Antioxidants and Sperm DNA Damage<br>Armand Zini and Maria San Gabriel</p><p>31. Sperm Chromatin and ART (IUI, IVF, and ICSI) Pregnancy<br>Mona Bungum</p><p>32. Sperm DNA Damage and Pregnancy Loss After IVF/ICSI<br>Armand Zini and Jason Matthew Boman</p><p>33. Postnatal Effects of Sperm Chromatin Damage<br>Miriam Pérez-Crespo, Raúl Fernández-González, Miguel Ángel Ramírez, Eva Pericuesta, Alexandra Calle, and Alfonso Gutiérrez-Adán</p><p>34. Evaluation of Chromatin and DNA Integrity in Testicular Sperm <br>Armand Zini and Naif Al-Hathal</p><p>V. Protocols and Integrity Tests</p><p>35. The Alkaline Comet Assay<br>Sheena E. M. Lewis </p><p>36. Sperm Chromatin Structure Assay (SCSA)<br>Donald P. Evenson </p><p>37. Measurement of DNA Damage in Spermatozoa by TUNEL Assay<br>Rakesh Sharma and Ashok Agarwal</p><p>38. Clinical Utility of Sperm DNA Integrity Tests<br>Armand Zini</p>

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        Sperm Chromatin