Allostasis, Homeostasis, and the Costs of Physiological Adaptation

Preface ix Contributors xi Introduction 1(16) Jay Schulkin 1 Principles of Allostasis: Optimal Design, Predictive Regulation, Pathophysiology, and Rational Therapeutics 17(48) Peter Sterling 2 Protective and Damaging Effects of the Mediators of Stress and Adaptation: Allostasis and Allostatic Load 65(34) Bruce S. McEwen 3 Merging of the Homeostat Theory with the Concept of Allostatic Load 99(14) David S. Goldstein 4 Operationalizing Allostatic Load 113(37) Burton Singer, Carol D. Ryff, and Teresa Seeman 5 Drug Addiction and Allostasis 150(14) George F. Koob and Michel Le Moal 6 Adaptive Fear, Allostasis, and the Pathology of Anxiety and Depression 164(64) Jeffrey B. Rosen and Jay Schulkin 7 A Chronobiological Perspective on Allostasis and Its Application to Shift Work 228(74) Ziad Boulos and Alan M. Rosenwasser 8 Allostatic Load and Life Cycles: Implications for Neuroendocrine Control Mechanisms 302(41) John C. Wingfield Commentary: Viability as Opposed to Stability: An Evolutionary Perspective on Physiological Regulation 343(22) Michael L. Power Index 365