Chapman, Audrey R.; Frankel, Mark S.

Designing Our Descendants

List of Contributors ix Preface xi PART I: Introduction 1 Framing the Issues 3(17) Audrey R. Chapman and Mark S. Frankel 2 Germ-Line Dancing: Definitional Considerations for Policy Makers 20(19) Eric Juengst and Erik Parens PART II: Scientific Considerations 3 Approaches to Gene Transfer to the Mammalian Germ Line 39(16) Theodore Friedmann 4 Scientific Methodologies to Facilitate Inheritable Genetic Modifications in Humans 55(13) Bhavani G. Pathak 5 Germ-Line Modification in Clinical Medicine: Is There a Case for Intentional or Unintended Germ-Line Changes? 68(9) R. Michael Blaese 6 Gene Repair, Genomics, and Human Germ-Line Modification 77(16) Kenneth W. Culver 7 Germ-Line Gene Therapy: Can We Do It, Do We Need It, Where Do We Start, and Where Might It Lead? 93(12) Christopher H. Evans PART III: Ethical and Religious Issues 8 The Moral Impasse in Human Embryo Research: Bypasses in the Making? 105(25) John Fletcher 9 The Implications of Inheritable Genetic Modifications for Justice 130(26) Audrey R. Chapman 10 The Hidden Eugenic Potential of Germ-Line Interventions 156(23) Troy Duster 11 Ethical Differences between Inheritable Genetic Modification and Embryo Selection 179(9) Bonnie Steinbock 12 Human Limits: Theological Perspectives on Germ-Line Modification 188(11) Ronald Cole-Turner 13 Germ-Line Intervention and the Moral Tradition of the Catholic Church 199(13) Albert Moraczewski 14 Uncountable as the Stars: Inheritable Genetic Intervention and the Human Future A Jewish Perspective 212(26) Laurie Zoloth 15 Parental Liberty and the Right of Access to Germ-Line Intervention: A Theological Appraisal of Parental Power 238(14) Sondra Wheeler 16 Inheritable Genetic Modifications: Do We Owe Them to Our Children? 252(23) Pilar N. Ossorio PART IV: Policy Issues 17 National Policies to Oversee Inheritable Genetic Modifications Research 275(21) Julie Gage Palmer and Robert Cook-Deegan 18 Designing Tomorrow's Children: The Right to Reproduce and Oversight of Germ-Line Interventions 296(15) Cynthia B. Cohen 19 To Market, To Market: Effects of Commerce on Cross-Generational Genetic Change 311(15) Mark S. Frankel and Michele S. Garfinkel 20 Recommendations for Policy 326(7) Mark S. Frankel and Audrey R. Chapman Appendix A. Consent Form for Participation in a Study of Inheritable Germ-Line Modification 333(14) Julie Gage Palmer Appendix B. AAAS Report on IGM: Major Findings, Concerns, and Recommendations 347(4) Appendix C. IGM Project Working Group 351(4) Index 355