Economic Evaluation in Clinical Trials

Series preface v Web resources vii Acknowledgment ix 1 Introduction 1 2 Designing economic evaluations in clinical trials 7 3 Valuing medical service use 31 4 Assessing quality-adjusted life years 59 5 Analyzing cost 89 6 Analyzing censored cost 115 7 Comparing cost and effect: point estimates for cost-effectiveness ratios and net monetary benefit 133 8 Understanding sampling uncertainty: the concepts 145 9 Sampling uncertainty: calculation, sample size and power, and decision criteria 179 10 Evaluating transferability of the results from trials 207 11 Relevance of trial-based economic analyses 229 Index 237