Makarov, Dmitrii E.

Introduction to Single Molecule Physics and Chemistry

The observation and manipulation of individual molecules is one of the most exciting developments in modern molecular science, and the utility of single-molecule methods has proven invaluable in such fields as nanoscience and molecular biology. This book provides a general framework necessary for understanding single-molecule phenomena. It introduces the relevant basic mathematical and physical concepts, and then discusses various approaches to the problem of interpreting single-molecule data. It thoroughly explains the physical principles underlying the major classes of single-molecule experiments, such as fluorescence measurements, force-probe spectroscopy, and nanopore experiments.