The Toxicology of Fishes

Acknowledgments xi The Editors xiii Contributors xv Unit I. General Principles Introduction 3(6) Richard T. Di Giulio David E. Hinton Bioavailability of Chemical Contaminants in Aquatic Systems 9(46) Russell J. Erickson John W. Nichols Philip M. Cook Gerald T. Ankley Toxicokinetics in Fishes 55(98) Kevin M. Kleinow John W. Nichols William L. Hayton James M. McKim Mace G. Barron Biotransformation in Fishes 153(82) Daniel Schlenk Malin Celander Evan P. Gallagher Stephen George Margaret James Seth W. Kullman Peter van den Hurk Kristie Willett Receptor-Mediated Mechanisms of Toxicity 235(38) Mark E. Hahn Eli V. Hestermann Reactive Oxygen Species and Oxidative Stress 273(54) Richard T. Di Giulio Joel N. Meyer Unit II. Key Target Systems and Organismal Effects Liver Toxicity 327(74) David E. Hinton Helmut Segner Doris W.T. Au Seth W. Kullman Ronald C. Hardman The Osmoregulatory System 401(16) Sjoerd E. Wendelaar Bonga Robert A.C. Lock Toxic Responses of the Fish Nervous System 417(40) Steven P. Bradbury Richard W. Carlson Tala R. Henry Stephanie Padilla John Cowden The Endocrine System 457(32) Peter Thomas The Immune System of Fish: A Target Organ of Toxicity 489(42) Erik Carlson Judith T. Zelikoff Chemical Carcinogenesis in Fishes 531(66) Jeanette M. Rotchell Michael R. Miller David E. Hinton Richard T. Di Giulio Gary K. Ostrander Toxicity Resistance 597(48) Peter A. Van Veld Diane E. Nacci Unit III. Methodologies and Applications Exposure Assessment and Modeling in the Aquatic Environment 645(14) Donald Mackay Lynne Milford Fish Toxicity Studies 659(24) Gary M. Rand Biomarkers 683(50) Daniel Schlenk Richard Handy Scott Steinert Michael H. Depledge William Benson Aquatic Ecosystems for Ecotoxicological Research: Considerations in Design Analysis for Fish 733(24) Thomas W. La Point James H. Kennedy Jacob K. Stanley Pinar Balci Ecological Risk Assessment 757(22) David R. Mount Tala R. Henry Unit IV. Case Studies Mining Impacts on Fish in the Clark Fork River, Montana: A Field Ecotoxicology Case Study 779(26) Samuel N. Luoma Johnnie N. Moore Aida Farag Tracy H. Hillman Daniel J. Cain Michelle Hornberger Toxicology of Synthetic Pyrethroid Insecticides in Fish: A Case Study 805(14) Joel R. Coats Reproductive Impairment of Great Lakes Lake Trout by Dioxin-Like Chemicals 819(58) Donald E. Tillitt Philip M. Cook John P. Giesy Warren Heideman Richard E. Peterson The Effects of Polycyclic Aromatic Hydrocarbons in Fish from Puget Sound, Washington 877(48) Lyndal L. Johnson Mary R. Arkoosh Claudia F. Bravo Tracy K. Collier Margaret M. Krahn James P. Meador Mark S. Myers William L. Reichert John E. Stein Effects of the Exxon Valdez Oil Spill on Pacific Herring in Prince William Sound, Alaska 925(8) Gary D. Marty Case Study: Pulp and Paper Mill Impacts 933(38) Monique G. Dube Kelly R. Munkittrick L. Mark Hewittxs Estrogenic Effects of Treated Sewage Effluent on Fish: Steroids and Surfactants in English Rivers 971(32) Charles R. Tyler Edwin J. Routledge Ronny van Aerle Index 1003