Epigenetic Cancer Therapy

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2015
ISBN13: 9780128002063
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Juridisch :
Elsevier Science e druk, 2015 9780128002063
Onderdeel van serie Translational Epigenetics
€ 130,60
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Samenvatting

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.

The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).

The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

Specificaties

ISBN13:9780128002063
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

1. Introduction<br>2. DNA Methylation & Hydroxymethylation in Cancer<br>3. Writers, Readers, and Erasers of Epigenetic Marks<br>4. MicroRNAs and Cancer<br>5. Long Noncoding RNAs (lncRNAs) and Cancer<br>6. Ribosomal RNA Methylation and Cancer<br>7. Mining the Epigenetic Landscape: Surface Mining or Deep Underground<br>8. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality<br>9. Epigenetic Therapy in Lung Cancer and Mesothelioma<br>10. Breast Cancer Epigenetics<br>11. Therapeutic Applications of the Prostate Cancer Epigenome<br>12. Liver Cancer (Hepatocellular Carcinoma)<br>13. Neuroblastoma<br>14. The Epigenetics of Medulloblastoma<br>15. Clinical Significance of Epigenetic Alterations in Glioblastoma<br>16. Esophageal Cancer<br>17. Nasopharyngeal Cancer<br>18. Nutritional Epigenetic Inhibitors in the Field of Cancer: New Avenues for Chemopreventive Approaches<br>19. Emerging Epigenetic Therapies – Lysine Methyltransferase/PRC Complex Inhibitors<br>20. Inhibitors of Jumonji C Domain Histone Demethylases<br>21. Emerging Epigenetic Therapies – Lysine Acetyltransferase Inhibitors<br>22. Emerging Epigenetic Therapies – Bromodomain Ligands<br>23. Clinical Trials<br>24. Genetic Intratumor Heterogeneity<br>25. Epigenetics Underpinning DNA Damage repair<br>26. Epigenetics of Cisplatin Resistance<br>27. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells<br>28. Personalized Therapy – Chemosensitivity Testing<br>29. Personalized Therapy - Epigenetic Profiling as Predictors of Prognosis and Response

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€ 130,60
Levertijd ongeveer 9 werkdagen
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        Epigenetic Cancer Therapy