Epigenetics of Aging and Longevity

<p>Section I: Epigenetic Mechanisms in Aging<br>1. Aging epigenetics: changes and challenges<br>2. Defective DNA methylation/demethylation processes define aging-dependent methylation patterns<br>3. S-adenosylmethionine Metabolism and Aging<br>4. The Epigenetic Clock and Ageing<br>5. The Epigenetic Regulation of Telomere Maintenance in Aging<br>6. Living Long and Ageing Well: Are Lifestyle factors the Epigenetic link in the Longevity Phenotype?<br>7. Epigenetic Biomarkers for Biological Age<br>8. The Role of Non-Coding RNAs in Genome Stability and Aging<br>9. Intra-tissue DNA methylation heterogeneity in aging</p> <p>Section II. Early-life Epigenetic Programming of Aging Trajectories<br>10. Early Life Nutrition, Epigenetics and Altered Energy Balance Later in Life<br>11. Early Nutrition, Epigenetics and Human Health<br>12. Biological Embedding of Psychosocial Stress over the Life Course<br>13. Epigenetics of longevity in social insects</p> <p>Section III. Epigenetics of Aging-Associated Diseases<br>14. Drosophila melanogaster as a Model for Studying the Epigenetic Basis of Aging<br>15. Histone modification changes during aging: Cause or Consequence? - What we have learned about epigenetic regulation of aging from model organisms<br>16. Epigenetics of brain/cognitive aging<br>17. The role of epigenetic modifications in cardiometabolic diseases<br>18. Epigenetic mechanisms in osteoporosis<br>19. Epigenetics of Skeletal Muscle Aging</p> <p>Section IV. Epigenome-targeted Therapies in Gerocscience<br>20. Healthy Aging and Epigenetic Drugs for Diabetes and Obesity: A Novel Perspective<br>21. Epigenetic Drugs for Cancer and Precision Medicine<br>22. Epigenetic Drug Discovery for Alzheimer’s Disease</p> <p>Section V. Conclusions and Perspectives<br>23. Epigenetics of aging and longevity: challenges and future directions</p>