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Epigenetics in Human Disease

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2018
ISBN13: 9780128122150
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Juridisch :
Elsevier Science e druk, 2018 9780128122150
Onderdeel van serie Translational Epigenetics
€ 185,80
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Samenvatting

Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders.

Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies.

Specificaties

ISBN13:9780128122150
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>Section I: Introduction<br>1. Epigenetics in Human Disease</p> <p>Section II: Methodology<br>2. Methods and Strategies to Determine Epigenetic Variation in Human Disease<br>3. Age Estimates Using DNA Methylation Patterns<br>4.Bioinformatics of Epigenetic Data Generated from Next-generation Sequencing</p> <p>Section III: Human Cancer<br>5. DNA Methylation Alterations in Human Cancers<br>6. Alterations of Histone Modifications in Cancer<br>7. MicroRNA in Cancer<br>8. Epigenetic Approaches to Cancer Therapy</p> <p>Section lV: Neurological Disease<br>9. Epigenomics in Neurobehavioral Disease<br>10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders<br>11. The Epigenetics of Alzheimer’s and Other Neurodegenerative Disease<br>12. Epigenetic Modulation of Human Neurobiological Disorder</p> <p>Section V: Autoimmune Disease<br>13. Epigenetic Basis of Autoimmune Disorders in Humans<br>14. Approaches to Autoimmune Diseases Using Epigenetic Therapy</p> <p>Section VI: Metabolic Disorders<br>15. Epigenomic Factors in Human Obesity<br>16. Epigenetic Approaches to Control Obesity<br>17. Epigenetics of Diabetes in Humans<br>18. The Potential of Epigenetic Compounds in Treating Diabetes</p> <p>Section VII: Other Disorders/Diseases<br>19. Epigenetic Aberrations in Human Allergic Diseases<br>20. Therapy of Airway Disease: Epigenetic Potential<br>21. The Role of Epigenetics in Cardiovascular Disease<br>22. Epigenetic Treatment Approaches to Cardiovascular Disease<br>23. Epigenetics and Human Infectious Diseases<br>24. Therapy of Infectious Diseases Using Epigenetic Approaches<br>25. The Epigenetics of Endometriosis<br>26. Epigenetic DNA Methylation in Endometrial Cancer<br>27. Epigenetic Treatment Prospects of Gynecological and Reproductive Diseases</p> <p>Section VIII: Development, Aging and Transgenerational Effects<br>28. Epigenetics of Transgenerational Inheritance in Disease<br>29. Epigenetic Mechanisms of Human Imprinting Disorders<br>30. Therapeutic Approaches to Imprinting Diseases<br>31. Stem Cell Epigenetics and Human Disease<br>32. Non-coding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy<br>33. Aging and Disease: The Epigenetic Bridge<br>34. Epigenetic Programming of Human Disease and Aging</p> <p>Section lV: Future Research<br>35. Future Directions in the Epigenetics of Human Disease</p>

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        Epigenetics in Human Disease