Rigor and Reproducibility in Genetics and Genomics

<p>SECTION 1 Introduction<br>1. Rigor and reproducibility in genetic research and the effects on scientific reporting and public discourse<br>2. Unveiling the hidden curriculum: Developing rigor and reproducibility values through teaching and mentorship<br> <br>SECTION 2 Genotyping<br>3. Genome-wide association studies (GWAS): hat are they, when to use them?<br>4. GWAS in the learning environment<br>5. Polygenic risk scores and comparative genomics: Best practices and statistical considerations<br>6. DNA sequencing and genotyping in the classroom<br>7. Classroom to career: Implementation considerations for engaging students with meaningful DNA sequencing learning opportunities<br> <br>SECTION 3 Next-generation sequencing & gene expression<br>8. Review of gene expression using microarray and RNA-seq<br>9. Guidelines and important considerations for ‘omics-level studies<br>10. Best practices for statistical analysis of omics data<br>11. Validation of gene expression by quantitative PCR<br><br>SECTION 4 Epigenetic analyses<br>12. Best practices for epigenome-wide DNA modification data collection and analysis<br>13. Best practices for the ATAC-seq assay and its data analysis<br>14. Best practice for ChIP-seq and its data analysis<br>15. A practical guide for essential analyses of Hi-C data<br>16. Epigenetics in the classroom<br><br>SECTION 5 Gene editing technologies<br>17. Genome editing technologies<br>18. Genetic modification of mice using CRISPR-Cas9: Best practices and practical concepts explained<br>19. CRISPR classroom activities and case studies</p>