From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors

<ol> <ol> <li>The computational modeling of allosteric modulation of metabotropic glutamate receptors</li> <p>Laura Pérez-Benito, Claudia Llinas del Torrent, Leonardo Pardo and Gary Tresadern</p> <p> <li>Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators</li> <p>Kirstie A. Bennett, John A. Christopher and Benjamin G. Tehan</p> <p> <li>The function and allosteric control of the human sweet taste receptor</li> <p>Guy Servant, Terry Kenakin, Lan Zhang, Mark Williams and Nicole Servant</p> <p> <li>The different aspects of the GABA<SUB>B</SUB> receptor allosteric modulation</li> <p>Julie Kniazeff</p> <p> <li>RAMPs as allosteric modulators of the calcitonin and calcitonin-like class B G protein-coupled receptors</li> <p>Augen A. Pioszak and Debbie L. Hay</p> <p> <li>Strategies and considerations of G-protein-coupled receptor photopharmacology</li> <p>Alice E. Berizzi and Cyril Goudet</p> <p> <li>Discovery and pharmacology of the covalent GLP-1 receptor (GLP-1R) allosteric modulator BETP. A novel tool to probe GLP-1R pharmacology</li> <p>Francis S. Willard, Joseph D. Ho and Kyle W. Sloop</p> <p> <li>Allosteric modulation of metabotropic glutamate receptors in alcohol use disorder: Insights from preclinical investigations</li> <p>Kari A. Johnson and David M. Lovinger</p> <p> <li>Allosteric modulation of muscarinic receptors in alcohol and substance use disorders</li> <p>Leigh C. Walker and Andrew J. Lawrence</p> <p> <li>M1 muscarinic acetylcholine receptors: A therapeutic strategy for symptomatic and disease-modifying effects in Alzheimer's disease?</li> </ol></ol> <p>Miriam Scarpa, Sarah Hesse and Sophie J. Bradley</p>