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Next Generation Sequencing in Cancer Research

Volume 1: Decoding the Cancer Genome

Specificaties
Gebonden, 383 blz. | Engels
Springer New York | 2013e druk, 2013
ISBN13: 9781461476443
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Springer New York 2013e druk, 2013 9781461476443
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​​​​This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology. 

Specificaties

ISBN13:9781461476443
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:383
Uitgever:Springer New York
Druk:2013

Inhoudsopgave

<p>1.      The evolution of high-throughput sequencing technologies: from Sanger to single molecule sequencing…..Chee-Seng Ku, Yudi Pawitan, Mengchu Wu, Dimitrios H. Roukos, David N. Cooper</p><p>2.      Next generation sequencing in cancer epigenomics and potential clinical applications….Hong Kiat Ng, Dimitrios H. Roukos, Barry Iacopetta, Chee-Seng Ku</p><p>3.      Next Generation Sequencing for Cancer Genomics…..Aarti N Desai and Abhay Jere</p><p>4.      Genomic Landscape of Cancer Metastasis….Arvind Kumar Singla, Chandini Thirukkumaran<sup> </sup>and Wei Wu</p><p>5.      Mapping the HIF transcription factor in cancer by ChIP-seq technology…..Johannes Schödel and David R. Mole</p><p>6.      Application of next-generation sequencing to analysis of TGFβ/SMAD4 targets in ovarian cancer…..Russell Bonneville, Kenneth Nephew, and Victor X. Jin</p><p>7.      Targeted Sequencing Strategies in Cancer Research…..HoJoon Lee, Billy T. Lau and Hanlee P. Ji</p><p>8.      Comprehensive genomic alterations in common cancer cell lines revealed by exome-sequencing…..Han Chang, Donald G. Jackson, Paul S. Kayne, Petra B. Ross-Macdonald, Rolf-Peter Ryseck, and Nathan O. Siemers</p><p>9.      Application of next generation sequencing in RNA biomarker discovery in cancer research…..Stephen P. Fink, and Kishore Guda</p><p>10.    Understanding the role of long non-coding RNAs in the cancer genome.....Wei Wu and Jennifer A. Chan</p><p>11.    Identification of piRNAs in HeLa cells by massive parallel sequencing.....Yilu Lu and Yongxin Ma</p><p>12.    microRNA expression in breast cancer revealed by deep sequencing technology.....Thalia A. Farazi, Carl S. Leonhardt, and Thomas Tuschl</p><p>13.    RNA-seq in prostate cancer research.....ShanCheng Ren, Min Qu, Yinghao Sun</p><p>14.    Next-generation sequencing for high-throughput RNA interference screens.....Toby M. Ward, Anna-Maria Jegg, and Elizabeth Iorns</p><p>15.    Assessment of Mapping and SNP-detection Algorithms for Next Generation Sequencing Data for Cancer Genomics.....Weixin Wang, Feng Xu, Junwen Wang</p><p>16.    Applications of very low coverage sequencing in cancer genomics ­ copy number, virus detection and survival.....Henry M Wood</p><p>17.    Tumor phylogenetics in the NGS era: Strategies, challenges and future prospects.....Ayshwarya Subramanian, Stanley Shackney and Russell Schwartz</p><p>18.    Impact and challenges in assessing tumor purity by next-generation sequencing…..Xiaoping Su, Gabriel G. Malouf, and Francisco J. Esteva</p>

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        Next Generation Sequencing in Cancer Research