Principles of Receptor Research

1 Blood-Brain Barrier: Techniques for the Intracerebral Administration of Drugs.- 1. Introduction.- 2. Characteristics of the Blood-Brain Barrier.- 3. Bypassing the Blood-Brain Barrier: Principles.- 4. Pharmacological Approach to the Internal or External Surface of the Brain.- 5. Drugs Administered to the Brain Parenchyma.- 6. Concluding Comment.- 7. References.- 2 Microiontophoretic Application of Drugs onto Single Neurons.- 1. Introduction.- 2. Basic Principles.- 3. Dispersal of Iontophoretically Applied Substances Within the Brain.- 4. Conclusions.- 5. References.- 3 Electrical Recording of Brain Activity: The EEG and Its Value in Assessing Drug Effects.- 1. Introduction.- 2. Selection of Animal Species.- 3. Acute Experiments.- 4. Chronic Implantation of Electrodes.- 5. Recording Procedures.- 6. Methods of Analyzing and Quantifying the EEG.- 7. Sensory Evoked Response Analysis.- 8. Focal Electrical Stimulation.- 9. Electrogenesis of the EEG and Evoked Potentials.- 10. Assessment of Alertness, Sedation, and the Stages of Sleep.- 11. Study of Sleep Patterns.- 12. Abnormal EEG Records.- 13. Transmitters and EEG Changes.- 14. Uses and Limitations of Macroelectrode Recordings.- 15. References.- 4 Neuropharmacological Responses from Nerve Cells in Tissue Culture.- 1. Introduction.- 2. Muscle.- 3. Continuous Cell Lines.- 4. Glia.- 5. Explants.- 6. Dissociated Primary Cell Cultures.- 7. Discussion.- 8. References.- 5 Biochemical Identification of Membrane Receptors: Principles and Techniques.- 1. Introduction.- 2. Properties of Receptor Interactions and Technical Considerations.- 3. Examples of Studies on Hormone-Membrane Receptor Interactions.- 4. Conclusions.- 5. References.- 6 Structure-Activity Relations for Neurotransmitter Receptor Agonists and Antagonists.- 1. Introduction.- 2. Norepinephrine.- 3. Dopamine.- 4. 5-Hydroxytryptamine.- 5. Acetylcholine.- 6. Histamine.- 7. References.- 7 Denervation Supersensitivity.- 1. Introduction.- 2. Quantitative Methods in the Study of Supersensitivity.- 3. Surgical and Pharmacological Denervation.- 4. Supersensitivity After Denervation of Sympathetically Innervated Organs.- 5. Supersensitivity After Denervation of Cholinergically Innervated Organs.- 6. Supersensitivity in the Central Nervous System.- 7. Clinical Implications of Supersensitivity and Subsensitivity.- 8. References.