The Reticuloendothelial System in Health and Disease

of Part A.- Section 1 Morphology and Surface Properties of Macrophages.- The RES and the Mononuclear Phagocyte System.- Structure and Function.- Relative Usefulness of the Terms RES and MPS.- References.- Morphology and Kinetics of Lymphocytes.- Acknowledgements.- References.- Differences Between Monocyte-Derived and Tissue Macrophages.- Materials and Methods.- Results.- Discussion.- References.- Cellular Basis for the Generation of B-Cell Diversity.- Distribution of T and B cells in Chickens.- The Thymus System.- The Bursal System.- Acknowledgements.- References.- Antigenic Differences Between Rat Alveolar and Peritoneal Macrophages.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- A Macrophage Cell Surface Antigen.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Section 2 Ontogeny and Development of RE Cells.- Origin, Ontogeny and Kinetics of Mononuclear Phagocytes.- Origin.- Ontogeny.- Kinetics.- Regulation.- Acknowledgements.- References.- Germinal Centers and Their Role in Immune Responses.- Acknowledgements.- References.- Distribution of HL-A Antigens and ABO Blood Groups in Pre-Columbian Mummies.- Materials and Methods.- Results.- Discussion.- References.- Immunological Reconstitution of Neonatally Thymectomized Rats Following Implantation of Thymic Epithelial Cells.- Materials and Methods.- Results.- Discussion.- References.- Section 3 Biochemistry and Physiology of the RES.- Biochemical Aspects of the Function of the Reticulo-Endothelial System.- Metabolism During Phagocytosis.- Ecto-Enzymes.- References.- Cyclic Nucleotide Metabolism of Reticuloendothelial Cells.- References.- Nitroblue Tetrazolium Reduction by Human Macrophages: Studies in Chronic Granulomatous Disease.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- The NADPH Oxidase Activity of Polymorphonuclear Neutrophilic Leukocytes Revisited.- Materials and Methods.- Results.- Discussion.- References.- Chemotaxis of Polymorphonuclear Neutrophilic Leukocytes by Mannan-Enriched Preparations of Candida albicans.- Materials and Methods.- Results.- Discussion.- References.- Iron and the Reticuloendothelial System.- Initial Diagnostic Tests.- Ferrokinetics.- Results of Ferrokinetic Studies.- Pathophysiology.- Therapy.- Acknowledgements.- References.- Section 4 The Phagocytic Event.- Chlorination, Decarboxylation and Bactericical Activity Mediated by the MPO-H2O2-Cl- System.- The MPO-H2O2-Halide Antimicrobial System.- Characteristics of MPO-H2O2 Cl-Reaction.- New Information and Physiological Activity.- Acknowledgements.- References.- The Mechanism of Control of Phagocytic Metabolism.- Acknowledgements.- References.- Genetic Regulation of Macrophage Functions.- Genetic Control of Phagocytic Activity.- Genetic Control of Antigen Handling.- References.- Electron Microscopic Cytochemical Localization of Intravenously Injected Liposome-Encapsulated Horseradish Peroxidase in Rat Liver Cells.- Material and Methods.- Results.- Discussion.- Acknowledgements.- References.- Phagocytosis and Intralysosomal Digestion of Subcellular Organelles by Kupffer Cells of Rat Liver.- Materials and Methods.- Results and Discussion.- Acknowledgements.- References.- The Role of Phagocytosis in the Production of Endogenous Pyrogen by Polymorphonuclear Leukocytes.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Antiphagocytic Activity of the Cell Wall Polysaccharide of Escherichia coli.- Materials and Methods.- Results.- Discussion.- References.- The Reticuloendothelial System (RES) in Experimental Amebic Meningoencephalitis.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Section 5 Factors Affecting RE Function.- The Selection and Design of Lysosomotropic Drugs.- Background and Nomenclature.- Physiologic Pathways to Vacuoles of Target Cells.- Selection and Design of Lysosomotropic Drugs.- Acknowledgements.- References.- Surface Receptors in B Lymphocyte Activation by Antigens.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Mechanisms of Lymphocyte Activation: Effect of Ligand Concentration and Induction Time.- Material and Methods.- Results.- Discussion.- Acknowledgements.- References.- Complement Independent Lipopolysaccharide (LPS) Induced Hypotension and Disseminated Intravascular Coagulation: A Correlation of LPS Structure with In vivo and In vitro Biological Activities.- Acknowledgements.- References.- Potentiated Lysosomal Enzyme, Bacteriostatic and Bactericidal Activities of Peritoneal Macrophages of Mice Treated with the MER Fraction of Tubercle Bacilli.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- Adjuvant Effect of Listeria Cell Wall Fraction.- Materials and Methods.- Results.- Discussion.- Acknowledgements.- References.- The Present View of RES and Shock.- RES Functions of Importance.- RES and Trauma Resistance.- RES Function in the Severely Injured.- Mechanism of the Post Traumatic RES Depression.- Clinical Implications.- Conclusions.- References.- Trauma Induced Histamine Synthesis and RES Activity.- Materials and Methods.- Results.- Discussion.- References.- Workshops.- RES — Biochemistry and Physiology.- RES Pharmacology.- Opening Remarks: The Last Tango in Pamplona.- Pharmacology of the Reticuloendothelial System Accent on Glucan.- References.- Zymosan, Glucan, Glucan Esters and Tilorone.- References.- Levamisole, an Anti-Anergic Chemotherapeutic Agent: Experimental and Clinical Findings.- References.- Clinical Experiences with Levamisole.- References.- Environmental Factors Affecting the RES.- Reticuloendothelial Blockade with Rare Earth Metals, the Role of Reticuloendothelial Activity in Hepatopathies and Intravascular Coagulation.- References.- Nutrition and Carcinogenesis.- Nutrients Modifying Chemical Carcinogenesis.- References.- From Concept to Clinical Trial: Search for a Host Defense System Stimulant.- From Sharks to Coenzyme Q10.- Two Macrophage-Affecting Agents (MER and AMS).- References.- Stimulation and Depression of RES Phagocytosis by Pharmacological Agents.- The Exploration of the Liver-Spleen Functionality Relation from the Animal to the Human.- Immunological Effects of Abused Drugs: Halothane, Promethazine and Oxisuran in Man.- References.- Drugs of Abuse: Effects on Immunity.- References.- Aspects of the Immunological Involvement in General Anesthesia: Transvascular Diapedesis, Circulatory Leukocytes and Phagocytosis.- References.- RES Depression by Promethazine Used in Pregnancy.- Oxisuran: A Non-Cytotoxic, Differentially Immunosuppressive Agent.- References.- Closing Remarks: Tangos for Mature Audiences.- List of Participants.