Formulation, Characterization, and Stability of Protein Drugs

A Compendium and Hydropathy/ Flexibility Analysis of Common Reactive Sites in Proteins: Reactivity at Asn, Asp, Gin, and Met Motifs in Neutral pH Solution.- Characterization, Stability, and Formulations of Basic Fibroblast Growth Factor.- The Characterization, Stabilization, and Formulation of Acidic Fibroblast Growth Factor.- Stability, Characterization, Formulation, and Delivery System Development for Transforming Growth Factor-Beta1.- Stability and Characterization of Recombinant Human Relaxin.- Interferon-?-1b (Betaseron®): A Model for Hydrophobic Therapeutic Proteins.- Characterization, Formulation, and Stability of Neupogen® (Filgrastim), a Recombinant Human Granulocyte-Colony Stimulating Factor.- Development and Shelf-Life Determination of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor (LEUKINE®, GM-CSF).- Formulation Development of an Antifibrin Monoclonal Antibody Radiopharmaceutical.- Biophysical Characterization and Formulation of TP40: A Chimeric Protein that Requires a pH-Dependent Conformational Change for Its Biological Activity.- Stability Characterization and Formulation Development of Recombinant Human Deoxyribonuclease I [Pulmozyme®, (Dornase Alpha)].