Membrane Microdomain Signaling
Lipid Rafts in Biology and Medicine
Samenvatting
Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.
Specificaties
Inhoudsopgave
Ephraim Yavin and Annette Brand
Regulatory Aspects of Membrane Microdomain (Raft) Dynamics in Live Cells: A Biophysical Approach
János Matkó and János Szöllosi
Lipid Raft Membrane Skeletons
Elizabeth J. Luna, Thomas Nebl, Norio Takizawa, and Jessica L. Crowley
Role of Cholesterol in Membrane Microdomain Signaling
Christopher J. Fielding
Raft Lipid Metabolism in Relation to Alkyl-Lysophospholipid-Induced Apoptosis
Arnold H. van der Luit, Marcel Verheij, and Wim J. van Blitterswijk
Role of Lipid Rafts in Signal Transduction and Synaptic Plasticity of Neural Cells
Markus Delling and Melitta Schachner
Role of Rafts in Virus Fusion and Budding
Wu Ou and Jonathan Silver
Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders
Mark P. Mattson, Roy G. Cutler, and Norman J. Haughey
Caveolin and Cancer: A Complex Relationship
Mordechai Liscovitch, Elke Burgermeister, Neeru Jain, Dana Ravid, Maria Shatz, and Lilach Tencer
Dietary Modulation of Lipid Rafts: Implications for Disease Prevention and Treatment
Mark P. Mattson
Index
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