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Small Molecule — Protein Interactions

Specificaties
Paperback, 228 blz. | Engels
Springer Berlin Heidelberg | 0e druk, 2012
ISBN13: 9783662053164
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Springer Berlin Heidelberg 0e druk, 2012 9783662053164
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Samenvatting

Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.

Specificaties

ISBN13:9783662053164
Taal:Engels
Bindwijze:paperback
Aantal pagina's:228
Uitgever:Springer Berlin Heidelberg
Druk:0

Inhoudsopgave

1 Drug Discovery Opportunities.- 2 Target Analysis: A Priori Assessment of Druggability.- 3 Drug Discovery at Signaling Interfaces.- 4 Chemical Genomics of Orphan Nuclear Receptors.- 5 High-Throughput X-Ray Techniques and Drug Discovery.- 6 NMR in Medicinal Chemistry.- 7 Creating Knowledge from High-Throughput Screening Data.- 8 From Structure to Recognition Principles: Mining in Crystal Data as a Prerequisite for Drug Design.- 9 Practical Database Screening with Docking Tools.- 10 De Novo Design Methods.- 11 From Protein Domains to Drug Candidates — Natural Products as Guiding Principles in Compound Library Design and Synthesis.- 12 Discovery of New MCRs, Chemical Evolution and Lead Optimization.- 13 The Impact of Combinatorial Chemistry on Drug Discovery.- Previous Volumes Published in This Series.

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        Small Molecule — Protein Interactions