Entry Inhibitors in HIV Therapy

Name: Entry Inhibitors in HIV Therapy
Author: Jacqueline D. Reeves

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Gebonden, blz. | Engels

Birkhäuser Basel | e druk, 2007

ISBN13: 9783764377823

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Birkhäuser Basel e druk, 2007 9783764377823

Onderdeel van serie Milestones in Drug Therapy

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Entry Inhibitors in HIV Therapy details the current status of this relatively new and very dynamic class of inhibitors. A unique overview of obstacles and accomplishments is presented. The impact of viral sequence diversity on this class of inhibitors is discussed, and a connection between basic research and clinical studies is shown. The book presents a unique collection of contributors from basic research, pharmaceutical research, and the clinic.

Specificaties

ISBN13:9783764377823

Taal:Engels

Bindwijze:gebonden

Uitgever:Birkhäuser Basel

Serie:Milestones in Drug Therapy

Inhoudsopgave

Introduction to entry inhibitors in the management of HIV infection.- The challenge of HIV sequence diversity in the envelope glycoproteins.- Attachment of human immunodeficiency virus to cells and its inhibition.- Inhibitors that target gp120-CD4 interactions.- Inhibitors that target gp120 interactions with coreceptor.- Inhibitors that target fusion.- Entry inhibitors as microbicides.- Entry inhibition of HIV-1 subtype C isolates.- The utility of coreceptor typing in the clinic.- Future clinical prospects for entry inhibitors.- Enfuvirtide: from basic science to FDA approval.- Targets for drug development – past and present.

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