New Therapeutic Targets in Rheumatoid Arthritis

Specificaties
Gebonden, 228 blz. | Engels
Birkhäuser Basel | 2009e druk, 2009
ISBN13: 9783764382377
Rubricering
Juridisch :
Birkhäuser Basel 2009e druk, 2009 9783764382377
Onderdeel van serie Progress in Inflammation Research
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

This volume focuses on therapeutic targets that were identified after TNF blockade. All these targets have recently been registered or are currently under development for the treatment of rheumatoid arthritis. Each chapter explores the biological rationale of a distinct therapeutic target in great detail. Readers will discover the latest in vitro work, animal models, and results from clinical trials.

Specificaties

ISBN13:9783764382377
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:228
Uitgever:Birkhäuser Basel
Druk:2009

Inhoudsopgave

B cell targets in rheumatoid arthritis.- Co-stimulatory pathways in the therapy of rheumatoid arthritis.- Immunobiology of IL-6 - Tocilizumab (Humanized anti-IL-6 receptor antibody ) for the treatment of RA.- Role of IL-1 in erosive arthritis, lessons from animal models.- Interleukin-15.- IL-17 and Th17 cells, key players in arthritis.- Role of il-18 in inflammatory diseases.- Chemokines and chemokine receptors.- Signaling pathways in rheumatoid arthritis.- Targeting oncostatin M in the treatment of rheumatoid arthritis.- Targeting the epigenetic modifications of synovial cells.- Perspectives in targeted therapy.

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        New Therapeutic Targets in Rheumatoid Arthritis