A Structural Perspective on Respiratory Complex I

<p>Foreword; Leonid Sazanov</p><p>Part I: Structure and mechanism of complex I<br>1. Structure of complex I; Rouslan Efremov and Leonid Sazanov<br>2. On the mechanism of the respiratory complex I; Thorsten Friedrich, Petra Hellwig, and Oliver Einsle<br>3. Iron–sulfur clusters in complex I; Eiko Nakamaru-Ogiso <br>4. Current Topics of the Inhibitors of Mitochondrial Complex I; Hideto Miyoshi <br>5. My Fifty Years Association with Complex I Study; Tomoko Ohnishi</p><p>Part II: Evolution of complex I<br>6. The Evolutionary Relationship between Complex I and [NiFe]-hydrogenase; Anne Volbeda and Juan C. Fontecilla-Camps<br>7. Recruitment of the antiporter module - a key event in complex I evolution; Vamsi Krishna Moparthi and Cecilia Hägerhäll</p><p>Part III: Mutations in complex I subunits and medical implications<br>8. Characterization of Bacterial Complex I (NDH-1) by a Genetic Engineering Approach; Takao Yagi, Jesus Torres-Bacete, Prem Kumar Sinha, Norma Castro-Guerrero, and Akemi Matsuno-Yagi <br>9. Cellular consequences of mtDNA-encoded mutations in NADH:ubiquinone oxidoreductase; Mina Pellegrini, Jan A.M. Smeitink, Peter H.G.M. Willems and Werner J.H. Koopman</p><p>Part IV: Subunit composition and assembly of mitochondrial complex I<br>10. The assembly of human complex I; Jessica Nouws, Maria Antonietta Calvaruso, Leo Nijtmans<br>11. Complexes I in the green lineage; Claire Remacle, Patrice Hamel, Véronique Larosa, Nitya Subrahmanian, Pierre Cardol</p><p>Part V: Supercomplexes in mitochondria<br>12. Supramolecular organization of the respiratory chain; Janet Vonck </p><p>Index</p>