Kinesins and Cancer

Specificaties
Gebonden, 230 blz. | Engels
Springer Netherlands | 2015e druk, 2015
ISBN13: 9789401797313
Rubricering
Juridisch :
Springer Netherlands 2015e druk, 2015 9789401797313
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting the importance of kinesins, summarising current knowledge and how they are shown to be crucial for mitosis. Chapters go on to explore how this family of proteins are emerging as a novel target for chemotherapeutic intervention and drug development.

Readers will learn how kinesins travel along microtubules to fulfill their many roles in intracellular transport or cell division. Several compounds that inhibit two mitotic kinesins (called Eg5 and CENP-E) have entered Phase I and II clinical trials and are explored in these chapters. Additional mitotic kinesins are currently being validated as drug targets, raising the possibility that the repertoire of kinesin-based drug targets may expand in the future.

The book is suitable as a reference standard for the field of kinesins and cancer. It will interest those in academia and pharmaceutical companies, and anyone with an interest in the medical relevance of these proteins, which cutting edge methodologies are now enabling us to understand in astonishing detail.

Specificaties

ISBN13:9789401797313
Taal:Engels
Bindwijze:gebonden
Aantal pagina's:230
Uitgever:Springer Netherlands
Druk:2015

Inhoudsopgave

<p>Preface     <br>                                                                                                             1 The kinesin superfamily<br>Kristen J. Verhey, Jared C. Cochran and Claire E. Walczak                        <br> <br>2 The discovery and development of Eg5 inhibitors for the clinic<br>James A.D. Good, G. Berretta, Nahoum G. Anthony and Simon P.Mackay                                                                                                     </p><p><p>3 Mechanism of action of Eg5 inhibitors<br>Robert A.Cross                                                                                                        </p><p><p>4 Clinical trials of mitotic kinesin inhibitors<br>Steven S.Rosenfeld                                                                                                  </p><p><p>5 Kif15; a useful target for anti-cancer therapy?<br>Roy G.H.P. van Heesbeen and Rene H.Medema  </p><p> 6 Down-regulating CENP-E activity: for better or for worse<br>Julien Espeut and ArianeAbrieu<br></p><p>7  The human kinesin-14 motor KifC1/HSET is an attractive anti-cancer drug target<br>Vaishali Pannu, Padmashree C.G. Rida and Ritu Aneja                                        <br><br>8  Kinesin-13 Microtubule Depolymerizing Proteins as targets for cancer therapy<br>Anutosh Ganguly and Fernando  Cabral                                                                    <br><br>9 Chromokinesins in genome maintenance and cancer<br>Manjari Mazumdar and Tom Misteli                                                                        <br><br>10 Kif14: a clinically relevent kineisn and potential target for cancer therapy<br>Brigitte L. Theriault and Timothy W. Corson                                                           <br><br>11 Kinesin-8 members and their potnetial as biomarker or therapeutic target<br>Thomas U. Mayer and Silke Hauf                                                                            <br><br>12 The kinesin-6 members MKLP1, MKLP2 and MPP1<br>Ryan D. Baron and Francis Barr                                                                             <br><br>13  Non-motor spindle proteins as cancer chemotherapy targets<br>Bob Margolis and Mythili Yenjerla                                                                           <br><br>14  Inhibitors of mitotic kinesins for cancer treatment: consequences for neurons<br>Olga I. Kahn and Peter Baas                                                                                                Index                                                                                                                           </p><p>            </p><p>            </p>

Net verschenen

Rubrieken

Populaire producten

    Personen

      Trefwoorden

        Kinesins and Cancer