In Vivo Inhalation Toxicity Screening Methods for Manufactured Nanomaterials

<div><div>1 The role of in vivo screening studies in assessing manufactured nanomaterials.- Part 1 Short Term Inhalation Study.- 2. The short-term inhalation study (STIS) as a range finder and screening tool in a tiered grouping strategy.- 3. Use of short-term inhalation study to obtain initial hazard data and prepare for subacute and subchronic inhalation studies, and toxicokinetic studies.- 4. Subchronic inhalation Toxicity Study with a Vapor Grown Carbon Nanofiber in Male and Female Rats (OECD 413) – Does nanofiber exposure have adverse impacts on the cardiovascular system?.- Part 2 Intratracheal Administration Study.- 5. Comparison of responses in rat lung following inhalation and intratracheal administration of nanoparticles.- 6. Standardization of intratracheal instillation study of manufactured nanomaterials.- 7. Sample preparation and the chracterization for Intratracheal Administration.- 8. Development of intra-tracheal intra-pulmonary spraying (TIPS) as an alternative assay method for testing chronic toxicity and carcinogenic potential of multiwall carbon nanotubes.- 9. Equivalence Criteria for Nanomaterials Developed from Results of a Comparative Study using Intratracheal Administration.- 10. Toxicokinetics of nano materials after the intratracheal administration.- 11. In Vitro Alveolar Epithelial Models toward the Prediction of Cytotoxicity Tests and Translocation Studies of Nanoparticles.&nbsp;<br></div></div>