The Many Faces of RNA

Introduction.<br>Overview:<br>RNA as a Therapeutic Target for Bleomycin, S.M. Hecht.<br>RNA: Chemistry, Structure and Interactions:<br>Synthetic RNA Modification and Cross-linking Approaches towards the Structure of the Hairpin Ribozyme and the HIV-1 Tat Protein Interaction with TAR RNA, M.J. Gait, D.J. Earnshaw, M.A. Farrow, and N.A. Naryshkin.<br>The Ribosome - The Universal Protein-synthesizing Machine, R. Brimacombe.<br>tRNA Recognition by Aminoacyl-tRNA Synthetases, S. Cusack, A. Yaremchuk, and M. Tukalo. RNA-Protein Recognition During RNA Processing and Maturation, G. Varani.<br>RNA as a Target/RNA as a Tool:<br>Exploiting RNA: Potential Targets, Screens and Drug Development, C.D. Prescott, L. Hegg, K. Nurse, R. Gontarek, H. Li, V. Emerick, T. Sterner, M. Gress, G. Thom, S. Guth, and D. Rispoli.<br>Structural Basis for Aminoglycoside Antibiotic Action, J.D. Puglisi.<br>Protein-RNA Recognition in a Highly Conserved Ribosomal Domain Targeted by Thiazole Antibiotics, D.E. Draper.<br>Rnase P and Its Substrate, L.A. Kirsebom.<br>Interfering with Gene Function at the RNA Level with Oligoymes - the Development of New Tools and Therapeutics, B.S. Sproat, S.T. George, M. Ma, and A.R. Goldberg.<br>Progress towards Therapeutic Application of SELEX-derived Aptamers, B. Polisky.<br>Catalysis of Organic Reactions by RNA - Strategies for the Selection of Catalytic RNAs, A. Jaschke.<br>Conclusions and Opportunities, B.W. Metcalf.<br>Appendix: Abstracts of Posters.<br>Index.