Advances in Immunology

<p>Contributors </p> <p>Early Steps of Follicular Lymphoma Pathogenesis <p>1. Follicular Lymphoma </p> <p>2. The Classical Model of Follicular Lymphomagenesis </p> <p>3. Circulating and Resident t(14;18) Cells Detected in Healthy Individuals are not Naive B-Cells </p> <p>4. The “Allelic Paradox”: A Particular Immuno/Genophenotype of t(14;18)+ Activated B-Cells Which Does Not Match Any of the Physiological Memory Subsets Present in Blood </p> <p>5. A Fraction of t(14;18) Cells in Healthy Carriers are Developmentally “Blocked” Follicular Lymphoma-Like Cells (FLLC) </p> <p>6. BCL2, BCL6, Maturation Arrest, and the Role of the IgM Receptor </p> <p>7. Trafficking, Early Dissemination, and Progression </p> <p>8. A Protracted Model of Multi-Hit FL Genesis </p> <p>9. Perspectives </p> <p>Acknowledgments </p> <p>“A Rose is a Rose is a Rose,” but CVID is Not CVID <p>1. Introduction </p> <p>2. Definition and Diagnostic Criteria </p> <p>3. Epidemiology </p> <p>4. Pathophysiology/Immunopathology </p> <p>5. Etiology/Genetics </p> <p>6. CVID Classification Schemes </p> <p>7. Clinical Presentation and Complications </p> <p>8. Management </p> <p>9. Prognosis and Survival </p> <p>10. Summary </p> <p>Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development <p>Abbreviations </p> <p>1. Introduction: Cancer as a Genetic Disease </p> <p>2. Nucleotide-Editing Enzymes as Inducers of Mutations </p> <p>3. Physiologic Roles of AID in Antibody Production </p> <p>4. Regulation of AID Expression in B Cells </p> <p>5. Excessive AID Activity and Genetic Alterations Leading to Tumorigenesis </p> <p>6. Roles of AID in Inflammation-Associated Human Carcinogenesis </p> <p>7. Role of AID in the Development of Hematopoietic Malignancy </p> <p>8. Conclusion </p> <p>Acknowledgments </p> <p>Comparative Genomics and Evolution of Immunoglobulin-Encoding Loci in Tetrapods <p>1. Introduction </p> <p>2. Structure and Function of Antibodies </p> <p>3. Ig-Heavy Chain in Tetrapods </p> <p>4. Ig-Light Chains in Tetrapods </p> <p>5. Evolution of Immunoglobulin J-Chain </p> <p>6. Noncanonical Antibodies in Camelids </p> <p>7. Concordance and Divergence of the Generation of Antibody Diversity </p> <p>8. Concluding Remarks </p> <p>Acknowledgments </p> <p>Pax5 <p>1. Pax5 and B Cell Commitment </p> <p>2. Pax5 and the Control of Igh Rearrangements </p> <p>3. Pax5 and Late B Cell Development </p> <p>4. Role of Pax5 in B Cell Malignancies </p> <p>5. Perspective </p> <p>Acknowledgments </p>