Enzymes of Epigenetics Part B

Specificaties
Gebonden, blz. | Engels
Elsevier Science | e druk, 2016
ISBN13: 9780128053812
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Juridisch :
Elsevier Science e druk, 2016 9780128053812
Onderdeel van serie Methods in Enzymology
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Samenvatting

Enzymes of Epigenetics: Part B, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field.

This volume covers research methods that are employed in the study of epigenetic regulation, including structural, biochemical, molecular, biological, cellular, computational, and systems approaches.

Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies, and small molecule epigenetic regulators and biological connections.

Specificaties

ISBN13:9780128053812
Taal:Engels
Bindwijze:Gebonden

Inhoudsopgave

<p>Epigenetic Technologies<br>1. Identification and Quantification of Histone PTMs using High-Resolution Mass Spectrometry<br>Kelly R. Karch, Simone Sidoli and Benjamin A. Garcia<br>2. Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray<br>Evan M. Cornett, Bradley M. Dickson, Robert M. Vaughan, Swathi Krishnan, Raymond C. Trievel, Brian D. Strahl, and Scott B. Rothbart<br>3. ArrayNinja: An Open Source Platform for Unified Planning and Analysis of Microarray Experiments<br>Bradley M. Dickson, Evan M. Cornett, Zachary Ramjan and Scott B. Rothbart<br>4. Chemical Biology Approaches for Characterization of Epigenetic Regulators<br>Dalia Barsyte-Lovejoy, Magdalena M Szewczyk, Panagiotis Prinos, Evelyne Lima-Fernandes, Suzanne Ackloo and Cheryl H. Arrowsmith<br>5. Mapping Lysine Acetyltransferase-Ligand Interactions by Activity-Based Capture<br>David C. Montgomery and Jordan L. Meier<br>6. Investigating Histone Acetylation Stoichiometry and Turnover Rate<br>Jing Fan, Josue Baeza and John M. Denu<br>7. Rapid Semisynthesis of Acetylated and Sumoylated Histone Analogs<br>Abhinav Dhall, Caroline E. Weller and Champak Chatterjee<br>8. An IF-FISH Approach for Co-Visualization of Gene Loci and Nuclear Architecture in Fission Yeast<br>Kyoung-Dong Kim, Osamu Iwasaki  and Ken-ichi Noma</p> <p>Small Molecule Epigenetic Regulators<br>9. Biology, Chemistry and Pharmacology of Sirtuins<br>Antonio Bedalov, Sarwat Chowdhury and Julian A. Simon<br>10. Synthesis and Assay of SIRT1 Activating Compounds<br>Han Dai , James L. Ellis , David A. Sinclair and Basil P. Hubbard<br>11. Synthesis and Assays of Inhibitors of Methyltransferases<br>Xiao-Chuan Cai, Kanishk Kapilashrami and Minkui Luo</p> <p>Epigenetics and Biological Connections<br>12. Exploring the Dynamic Relationship between Cellular Metabolism and Chromatin Structure using SILAC-Mass Spec and ChIP-Sequencing<br>Philipp Mews and Shelley L. Berger<br>13. Current Proteomic Methods to Investigate the Dynamics of Histone Turnover in the Central Nervous System<br>Lorna A. Farrelly, Brian D. Dill, Henrik Molina, Marc R. Birtwistle and Ian Maze<br>14. ChIP-Sequencing to Map the Epigenome of Senescent Cells using Benzonase Endonuclease<br>Taranjit Singh Rai and Peter D. Adams<br>15. Exploiting Chromatin Biology to Understand Immunology<br>John L. Johnson and Golnaz Vahed</p>

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        Enzymes of Epigenetics Part B