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Cancer-Leading Proteases

Structures, Functions, and Inhibition

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Paperback, blz. | Engels
Elsevier Science | e druk, 2020
ISBN13: 9780128181683
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Elsevier Science e druk, 2020 9780128181683
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Samenvatting

Cancer-Leading Proteases: Structures, Functions, and Inhibition presents a detailed discussion on the role of proteases as drug targets and how they have been utilized to develop anticancer drugs. Proteases possess outstanding diversity in their functions. Because of their unique properties, proteases are a major focus of attention for the pharmaceutical industry as potential drug targets or as diagnostic and prognostic biomarkers. This book covers the structure and functions of proteases and the chemical and biological rationale of drug design relating to how these proteases can be exploited to find useful chemotherapeutics to fight cancers.

In addition, the book encompasses the experimental and theoretical aspects of anticancer drug design based on proteases. It is a useful resource for pharmaceutical scientists, medicinal chemists, biochemists, microbiologists, and cancer researchers working on proteases.

Specificaties

ISBN13:9780128181683
Taal:Engels
Bindwijze:Paperback

Inhoudsopgave

1. Proteases and Their Biological Roles and Mechanism of Action<br>2. Specificity and Diversity in Proteases<br>3. Potential Roles of Protease Inhibitors in Cancer Progression<br>4. Serine Proteases in Ovarian Cancer<br>5. Aspartic Proteases as Potential Drug Targets for Anticancer Drug Development<br>6. Design and Development of Serine Proteases Acting against Prostate Cancer<br>7. Urokinase and Colorectal Carcinoma: Studies on Mechanism and Inhibition<br>8. Overexpression of Cystein Proteases and Colorectal Carcinoma<br>9. Studies on Cystein Proteases and Their Inhibitors for Anti-cancer Drug Design<br>10. Gelatinases and Anticancer Drug Development<br>11. HCV NS3 Serine Protease as a Drug Target for Development of Drugs Against Liver Cancer<br>12. Molecular Imaging of Proteases in Cancer

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        Cancer-Leading Proteases