The Design and Development of Novel Drugs and Vaccines

<p>1. Introduction of structural bioinformatics with respect to drug discovery<br>2. Target identification and validation<br>3. Retrieval of compounds<br>4. Lead identification and optimization<br>5. Molecular dynamics simulations<br>6. An overview of vaccine design<br>7. Key steps in the selection of vaccine targets<br>8. Epitope prediction and selection of linkers and adjuvant<br>9. Design of vaccine constructs<br>10. In-silico validation through protein-protein docking<br>11. Molecular cloning<br>12. Protein expression<br>13. Protein purification and desalting<br>14. Biological assay<br>15. Biophysical methods<br>16. Outline of animal study for lead/ vaccine testing<br>17. Evaluation of immunogenicity of vaccine candidate<br>18. In-vitro evaluation of lead molecule<br>19. Medical physiological parameter for lead/vaccine testing<br>20. Brief introduction of clinical research and trials<br>21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance<br>22. Introduction of Intellectual property rights</p>