The Three Functional States of Proteins

Name: The Three Functional States of Proteins
Author: Timir Tripathi

Structured, Intrinsically Disordered, and Phase Separated

Specificaties

Paperback, blz. | Engels

Elsevier Science | e druk, 2024

ISBN13: 9780443218095

Rubricering

Juridisch :

Elsevier Science e druk, 2024 9780443218095

€ 195,40

In winkelwagen

Levertijd ongeveer 9 werkdagen

Gratis verzonden

Samenvatting

The Three Functional States of Proteins explores how structured proteins, intrinsically disordered proteins, and phase separated proteins contribute to the complexity of cellular life, and offers insights into their roles in both health and disease. It discusses the latest research findings and highlight groundbreaking discoveries and innovative methodologies used to study these protein states.
Traditionally, the different states of proteins have been defined based on their structures and functions. However, it is becoming increasingly clear that these criteria alone may not be sufficient to capture the complex and multifaceted properties of these molecules. Definitions based on thermodynamics and kinetics are now recognized as potentially more appropriate for comprehensively understanding protein states. Emerging evidence indicates that under physiological conditions, a majority of proteins possess the capability to exist in and transition between the native, droplet, and amyloid states. These distinct states play crucial roles in various cellular functions, influenced significantly by their physicochemical and structural properties. The book also considers the interactions among these states and discusses how their internal organization as individual molecules, as well as their collective organization as molecular assemblies are stabilized. Furthermore, it examines the processes by which these states are formed and the cellular functions associated with each specific state.

Specificaties

ISBN13:9780443218095

Taal:Engels

Bindwijze:Paperback

Uitgever:Elsevier Science

Inhoudsopgave

1. The three functional states of proteins: Beyond the classical “lock-and-key” paradigm 2. Ordered proteins and structure-function relationship: Classical view 3. Binding of a substrate (“lock and key”) and conformational adaption (“induced fit”) are different stages of enzyme action 4. Intrinsically disordered proteins: Functionality of chaos 5. Protein Conformation-based Phenotypic Switching and Implications in the Origin and Evolution of Multicellularity 6. Hybrid proteins: Fusion chimeras and natural wonders 7. Functional protein oligomers 8. Fuzzy complexes 9. SMARTQ: Single Molecule Amyloid fibRil Tracking and Quantification. A method for accurately imaging, tracking and quantifying the growth of individual amyloid fibrils using TIRF 10. Structural Polymorphism in Amyloids – States within Proteins’ Solid-State 11. Liquid-Liquid Phase Separation, Biomolecular Condensates and Membraneless Organelles: A Novel Blueprint of Intracellular Organization 12. Physical principles and molecular interactions underlying protein phase separation 13. Various levels of phase transitions in the protein universe 14. Targeting phase-separated protein states for drug discovery 15. Protein hydrogels: Structure, Characteristics, and Applications 16. Interactions among the three protein states 17. Protein frustration and fuzziness in the three functional states 18. Thermoresponsive intrinsically disordered protein polymers 19. The evolution and exploration of intrinsically disordered and phase-separated protein states 20. Computational modelling of intrinsically disordered and phase separated protein states 21. Molecular dynamics simulations of intrinsically disordered, fuzzy complexes, and phase separated protein states 22. Biological complexity of the phase separated protein states 23. Protein structure-function continuum

Uw winkelwagen

The Three Functional States of Proteins

Structured, Intrinsically Disordered, and Phase Separated

Samenvatting

Specificaties

Inhoudsopgave

Net verschenen

Rubrieken

Personen

Trefwoorden