, ,

Epigenetics in Human Disease

Specificaties
Paperback, blz. | Engels
Elsevier Science | e druk, 2023
ISBN13: 9780443218118
Rubricering
Juridisch :
Elsevier Science e druk, 2023 9780443218118
Onderdeel van serie Translational Epigenetics
€ 289,00
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Samenvatting

Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice.

Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies.

Specificaties

ISBN13:9780443218118
Taal:Engels
Bindwijze:paperback

Inhoudsopgave

<p>Section I: Introduction<br>1. Epigenetics of Human Disease: An Overview</p> <p>Section II: Methodology<br>2. Methods and Strategies to Determine Epigenetic Variation in Human Disease<br>3. DNA Methylation–Based Measures of Biological Aging<br>4. Bioinformatics of Epigenomic Data Generated From Next-Generation Sequencing</p> <p>Section III: Human Cancer <br>5. DNA Methylation Alterations in Human Cancer<br>6. Alterations of Histone Modifications in Cancer<br>7. MicroRNA in Cancer<br>8. Epigenetic Approaches to Cancer Therapy</p> <p>Section IV: Neurological Disease<br>9. Epigenetics in Neurobehavioral Disease<br>10. Emerging Role of Epigenetics in Human Neurodevelopmental Disorders<br>11. The Epigenetics of Alzheimer's and Other Neurodegenerative Disorders<br>12. Epigenetic Modulation of Human Neurobiological Disorders</p> <p>Section V: Autoimmune Disease<br>13. Epigenetic Basis of Autoimmune Disorders in Humans<br>14. Approaches to Autoimmune Diseases Using Epigenetic Therapy</p> <p>Section VI: Metabolic Disorders<br>15. Epigenomics and Human Obesity<br>16. Epigenetic Approaches to Control Obesity<br>17. Early-Life Nutrition, Epigenetics and Prevention of Obesity<br>18. Epigenetics of Diabetes in Humans<br>19. The Potential of Epigenetic Compounds in Treating Diabetes</p> <p>Section VII: Other Disorders/Diseases<br>20. Epigenetic-Processes Driven Disorders and Therapeutics<br>21. Epigenetics of Allergic Diseases Allergies, Eczema, Asthma, and Rhinitis<br>22. Therapy of Airway Disease:  Epigenetic Potential<br>23. The Role of Epigenetics in Cardiovascular Disease <br>24. Epigenetic Treatment Approaches to Cardiovascular Disease<br>25. Epigenetics and Human Infectious Diseases<br>26. Therapy of Infectious Diseases Using Epigenetic Approaches<br>27. Translational Aspects of the Endometriosis Epigenome<br>28. Aberrant DNA Methylation Patterns in Gynecologic Cancers: Implications for Prevention and Therapy <br>29. Epigenetics in Human Reproduction and Gynecologic Diseases</p> <p>Section VIII: Development, Aging and Transgenerational Effects<br>30. Epigenetics of Transgenerational Inheritance of Disease<br>31. Epigenomic Mechanisms of Human Developmental Disorders<br>32. Therapeutic Approaches to Imprinting Diseases<br>33. Stem Cell Epigenetics and Human Disease<br>34. Noncoding RNA Regulatory Networks, Epigenetics, and Programming Stem Cell Renewal and Differentiation: Implications for Stem Cell Therapy<br>35. Aging and Disease: The Epigenetic Bridge<br>36. Epigenetic Programming of Human Disease and Aging</p> <p>Section IX: Future Research<br>37. Epigenetic Prospects in Epidemiology and Public Health</p>

Net verschenen

€ 289,00
Levertijd ongeveer 9 werkdagen
Gratis verzonden

Rubrieken

    Personen

      Trefwoorden

        Epigenetics in Human Disease