50 Years of DNA

Foreword Remarks from Phil Campbell Preface; J.Clayton & C.Dennis PART I: HISTORY On the Shoulders of Giants : The Quest to Solve DNA? 1953 Revisited What Happened Next: The Golden Years of Molecular Biology PART II: THE PRESENT Where AreThey Now? Structural Biology: Still Going Strong Genomes Galore Window on Evolution 'Artificial Evolution': Maize, Wheat, Rice Domestication PART III: THE FUTURE DNA as a Tool in Disease Diagnosis and Therapy DNA and Culture The Genie's Out PART IV: THE DOUBLE HELIX - 50 YEARS The Eternal Molecule; C.Dennis &P.Campbell PART V: FACSIMILE PAPERS FROM NATURE , 25 APRIL 1953 A Structure for Deoxyribose Nucleic Acid ( Nature 171, 737-738; 1953); J.D.Watson & F.H.C.Crick Molecular Structure of Deoxypentose Nucleic Acids ( Nature 171, 738-740; 1953); M.H.F.Wilkins, A.R.Stokes & H.R.Wilson Molecular Configuration in Sodium Thymonucleate ( Nature 171, 740-741; 1953), R.E.Franklin & R.G.Gosling HISTORICAL BACKGROUND Quiet Debut for the Double Helix; R.Olby Discovering Genes are Made of DNA; M.McCarty DNA and the 'Wronged Heroine'; B.Maddox PART VI: DNA IN MEDICINE AND SOCIETY The Mosaic That is Our Genome; S.Pääbo Nature, Nurture and Human Disease; A.Chakravarti & P.Little The Double Helix in Clinical Practice; J.I.Bell The Mona Lisa of Modern Science; M.Kemp PART VII: DNA: THE BIOLOGICAL MOLECULE Portrait of a Molecule; P.Ball Ten Years of Tension: Single-Molecule DNA Mechanics; C.Bustamante, Z.Bryant & S.B.Smith DNA in a Material World; N.C.Seeman DNA Replication and Recombination; B.Alberts DNA Damage and Repair; E.C.Freidberg The Double Helix and Immunology; G.J.V.Nossal The Digital Code of DNA; L.Hood & D.Galas Controlling the Double Helix; G.Felsenfeld & M.Groudine