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Biochemistry of Pulmonary Emphysema

Specificaties
Paperback, 200 blz. | Engels
Springer London | 0e druk, 2014
ISBN13: 9781447137733
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Springer London 0e druk, 2014 9781447137733
Onderdeel van serie Current Topics in Rehabilitation
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Pulmonary emphysema is a disease which develops because of a localized imbalance between endogenous proteinase inhibitors and proteinases leaking from neurophils during phagocytosis at inflammatory foci within the lung. This volume not only reviews at a biochemical level what is known about the natural inhibitors and proteinases involved in connective tissue destruction within the lung, but also suggests novel methodologies for reestablishing proper enzyme-inhibitor balance, including the use of natural or synthetic inhibitors for supplementation or gene therapy.

Specificaties

ISBN13:9781447137733
Taal:Engels
Bindwijze:paperback
Aantal pagina's:200
Uitgever:Springer London
Druk:0

Inhoudsopgave

From the Contents: Pulmonary Emphysema: What's going on.- Elastin and the Lung.- An Introduction to the Endopeptidases.- Lung Proteinase and Emphysema.- Multiple Functions of Neutrophil Proteinases and their Inhibitor Complexes.- Kinetics of the Interaction of Human Leucocyte Elastase with Protein Substrates.- Proteinase Inhibitor Candidates for Therapy of Enzyme-Inhibitor Imbalances.- Antileucoprotease (Secretory Leucocyte Proteinase Inhibitor), A Major Proteinase Inhibitor in the Human Lung.- Development and Evaluation of Antiproteases as Drugs for Preventing Emphysema.- Genetic Control of Human Alpha-1-Antitrypson and Hepatic Gene Therapy.- Neutrophils, Neutrophil Elastase and the Fragile Lung.

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        Biochemistry of Pulmonary Emphysema