Biological Reactive Intermediates IV

Sessions I – VI.- Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates.- Formation of Reactive Intermediates by Phase II Enzymes: Glutathione-Dependent Bioactivation Reactions.- Role of the Well-Known Basic and Recently Discovered Acidic Glutathione S-Transf erases in the Control of Genotoxic Metabolites.- Bioactivation of Xenobiotics by Flavin-Containing Monooxygenases.- Formation of Biological Reactive Intermediates By Peroxidases: Halide Mediated Acetaminophen Oxidation and Cytotoxicity.- Peroxyl Free Radicals: Biological Reactive Intermediates Produced During Lipid Oxidation.- Biological Significance of Active Oxygen Species: In Vitro Studies on Singlet Oxygen-Induced DNA Damage and on the Singlet Oxygen Quenching Ability of Carotenoids, Tocopherols and Thiols.- Physiological and Toxicological Roles of Hydroperoxides.- Overview: Theoretical Aspects of Isotope Effects on the Pattern of Metabolites Formed by Cytochrome P-450.- S-Thiolation of Protein Sulfhydryls.- Cytochrome P-450 as a Target of Biological Reactive Intermediates.- Hapten Carrier Conjugates Associated with Halothane Hepatitis.- Metabolism of Drugs by Activated Leukocytes: Implications for Drug-Induced Lupus and Other Drug Hypersensitivity Reactions.- Formation of Reactive Metabolites and Appearance of Anti-Organelle Antibodies in Man.- Formation of a Protein-Acetaldehyde Adduct in Liver During Chronic Alcohol Exposure.- Dose-Response Relationships in Chemical Carcinogenesis: From DNA Adducts to Tumor Incidence.- The Single Cell Gel (SCG) Assay: An Electrophoretic Technique for the Detection of DNA Damage in Individual Cells.- Monitoring Human Exposure to Environmental Carcinogens.- Comparing the Frequency and Spectra of Mutations Induced When an SV40-Based Shuttle Vector Containing Covalently Bound Residues of Structurally-Related Carcinogens Replicates in Human Cells.- Molecular Targets of Chemical Mutagens.- Mutagenic Consequences of the Alteration of DNA by Chemicals and Radiation.- Gene Specific Damage and Repair After Treatment of Cells with UV and Chemotherapeutical Agents.- Proto-Oncogene Activation in Rodent and Human Tumors.- Short Communications.- Toxicity of 3-Methyleneoxindole, A Proposed Reactive Intermediate in the Metabolism of 3-Methylindole.- The Role of Cytochrome P450IIE1 in Bioactivation of Acetaminophen in Diabetic and Acetone-Treated Mice.- Arylamine-Induced Hemolytic Anemia: Electron Spin Resonance Spectrometry Studies.- Selective Alterations in the Profiles of Newly Synthesized Proteins by Acetaminophen (APAP) and Its Dimethylated Analogues: Relationship to Oxidative Stress.- Benzene Metabolism by Two Purified, Reconstituted Rat Hepatic Mixed Function Oxidase Systems.- Stereochemical Induction of Cytochrome P450IVA1 (P452) and Peroxisome Proliferation in Male Rat.- Cyanide Liberation and Oxidative Stress by Organothiocyanates, Organonitriles and Nitroprusside in Isolated Hepatocytes.- Mixed Function Oxidase Enzyme Responses to In Vivo and In Vitro Chromate Treatment.- Fatty Acid ?-Oxidation-Dependent Bioactivation of 5,6-Dichloro-4-Thia-5-Hexenoate and Analogs in Isolated Rat Hepatocytes.- Role of the Acetone Inducible P-450IIE1 in the Deethylation of Diethylnitrosamine In Hamster.- Stereochemistry of the Microsomal Glutathione S-Transferase-Catalyzed Addition of Glutathione to Chlorotrifluoroethene in Isolated Rat Hepatocytes.- The Pathophysiological Significance of Reactive Oxygen Formation in Rat Liver.- Oxidative Stress During Hypoxia in Isolated-Perfused Rat Heart.- Alteration of Growth Rate and Fibronectin by Imbalances in Superoxide Dismutase and Glutathione Peroxidase Activity.- The Antidotal Activity of the Thiol Drug Diethyldithiocarbamate Against N-Acetyl-p-Benzoquinone Imine in Isolated Hepatocytes.- Two Classes of Azo Dye Reductase Activity Associated with Rat Liver Microsomal Cytochrome P-450.- Expression of a cDNA Encoding Rat Liver DT-Diaphorase in Escherichia Coli.- Suicidal Inactivation of Cytochrome P-450 by Halothane and Carbon Tetrachloride.- Structure-Activity Relationships of Acrylate Esters: Reactivity Towards Glutathione and Hydrolysis by Carboxylesterase In Vitro.- Glutathione Conjugates of Hydralazine Formed in Theperoxidase/Hydrogen Peroxide/Glutathione System.- Contribution of 3,4-Dichlorophenylhydroxylamine in Propanil-Induced Hemolytic Anemia.- A Reduction in Mixed Function Oxidases and in Tumor Promoting Effects of Ethanol in a NDEA-Initiated Hepatocarcinogenesis Model.- Selective Inducers of the Coh-Locus Enhance the Metabolisms of Cou marin- and of Quinoline-Derivatives But Not That of Naphthalenes.- Primaquine-Induced Oxidative Stress in Isolated Hepatocytes as a Result of Reductive Activation.- Nitroprusside: A Potpourri of Biologically Reactive Intermediates.- Denitrosation of N-Nitrosodimethylamine in the Rat In Vivo.- Effect of Phenol and Catechol on the Kinetics of Human Myeloperoxidase-Dependent Hydroquinone Metabolism.- Activation of 1-Hydroxymethylpyrene to an Electrophilic and Mutagenic Metabolite by Rat Hepatic Sulfotransferase Activity.- Bioactivation of 2,6-Di-Tert-Butyl-4-Methyl Phenol (BHT) and Hydroxylated Analogues to Toxic Quinoid Metabolites.- Further Evidence for the Role of Myeloperoxidase in the Activation of Benzo[A]Pyrene-7,8-Dihydrodiol by Polymorpho-Nuclear Leukocytesm.- Quinones and Their Glutathione Conjugates as Irreversible Inhibitors of Glutathione S-Transferases.- Cytochrome P450 IA2 Activity in Man Measured by Caffeine Metabolism: Effect of Smoking, Broccoli, and Exercise.- Tissue Difference in Expression of Cytochrome P-450 Between Liver and Lung of Syrian Golden Hamsters Treated with 3-Methylcholanthrene.- Session VII – XII.- Role of Calcium in Toxic and Programmed Cell Death.- Molecular Mechanisms of ?-Diketone Neuropathy.- Microtubule Assembly Is Altered Following Covalent Modification by the n-Hexane Metabolite 2,5-Hexanedione.- The Role of Hepatic Metabolites of Benzene in Bone Marrow Peroxidase-Mediated Myelo- and Genotoxicity.- Glutathione Conjugation as a Mechanism of Targeting Latent Quinones to the Kidney.- Hepatic Bioactivation of 4-Vinylcyclohexene to Ovotoxic Epoxides.- Testicular Metabolism and Toxicity of Halogenated Propanes.- Lung Vascular Injury from Monocrotaline Pyrrole, a Putative Hepatic Metabolite.- Reactive Oxygen Species in the Progression of CCl4-Induced Liver Injury.- Parenchymal and Nonparenchymal Cell Interactions in Hepatotoxicity.- Signal Paths and Regulation of Superoxide, Eicosanoid, and Cytokine Formation in Macrophages of Rat Liver.- Reactive Metabolites from N-Nitrosamines.- Bisfuranoid Mycotoxins: Their Genotoxicity and Carcinogenicity.- Covalent Bonding of Bay-Region Diol Epoxides to Nucleic Acids.- Electrophilic Sulfuric Acid Ester Metabolites of Hydroxy-Methyl Aromatic Hydrocarbons as Precursors of Hepatic Benzylic DNA Adducts In Vivo.- Heterocyclic Amines: New Mutagens and Carcinogenes in Cooked Foods.- Acetaminophen and Protein Thiol Modification.- Formation and Reactivity of a Quinone Methide in Biological Systems.- Mechanisms for Pyrrolizidine Alkaloid Activation and Detoxification.- Sulfur Conjugates as Putative Pneumotoxic Metabolites of the Pyrrolizidine Alkaloid, Monocrotaline.- The Metabolism of Benzene to Muconic Acid, A Potential Biological Marker of Benzene Exposure.- Lessons on the Second Cancers Resulting from Cancer Chemotherapy.- Genetic Polymorphism of Drug Metabolism in Humans.- Human Health Risk Assessment and Biological Reactive Intermediates: Hemoglobin Binding.- Quantitating the Production of Biological Reactive Intermediates in Target Tissues: Example, Dichloromethane.- Trapping of Reactive Intermediates by Incorporation of 14C-Sodium Cyanide During Microsomal Oxidation.- Multiple Bioactivation of Chloroform: A Comparison Between Man and Experimental Animals.- Short Communications.- CCl4-Induced Cytochrome P-450 Loss and Lipid Peroxidation in Rat Liver Slices.- Alteration of Benzo(A)Pyrene-DNA Adduct Formation by Rats Exposed to Simple Mixtures.- Comparison of the Toxicity of Naphthalene and Naphthalene-1,2-Dihydrodiol (DIOL).- Selective Binding of Acetaminophen (APAP) to Liver Proteins in Mice and Men.- Post-Treatment Protection with Piperonyl Butoxide Against Acetaminophen Hepatotoxicity is Associated with Changes in Selective But Not Total Covalent Binding.- Covalent Binding of a Halothane Metabolite and Neoantigen Production in Guinea Pig Liver Slices.- Extensive Alteration of Genomic DNA and Rise in Nuclear Ca2+In Vivo Early After Hepatotoxic Acetaminophen Overdose in Mice.- The Possible Role of Glutathione on the Hepatotoxic Effect of Papaverine Hydrochloride In Vitro.- In Vivo and In Vitro Evidence for In Situ Activation and Selective Covalent Binding of Acetaminophen (APAP) in Mouse Kidney.- Metabolism of Dichlorobenzenes in Organ Cultured Liver Slices.- Inhibition of Protein Synthesis and Secretion by Volatile Anesthetics in Guinea Pig Liver Slices.- Dichlorobenzene Hepatotoxicity Strain Differences and Structure Activity Relationships.- The Use of 19F NMR in the Study of Protein Alkylation by Fluorinated Reactive Intermediates.- S-Ethylthiotrifluoroacetate Enhancement of the Immune Response to Halothane in the Guinea Pig.- Bone Marrow DNA Adducts and Bone Marrow Cellularity Following Treatment with Benzene Metabolites In Vivo.- The Role of ?-Glutamyl Transpeptidase in Hydroquinone-Glutathione Conjugate Mediated Nephrotoxicity.- Cytochrome P450IIE1 Metabolism of Pyridines: Evidence for Production of a Reactive Intermediate Which Exhibits Redox-Cycling Activity and Causes DNA Damage.- Morphological Cell Transformation and DNA Adduction by Benz(J)Aceanthrylene and Its Presumptive Reactive Metabolites in C3H10T1/2CL8 Cells.- Covalent Binding of Oxidative Biotransformation Reactive Intermediates to Protein Influences Halothane-Associated Hepatotoxicity in Guinea Pigs.- The Nephrotoxicity of 2,5-Dichloro-3-(Glutathion-S-YL)-1,4-Benzo-Quinone. and 2,5,6-Trichloro-3-(Glutathion-S-YL)-1,4-Benzoquinone Is Potentiated by Ascorbic Acid and AT-125.- Generation of Free Radicals Results in Increased Rates of Protein Degradation in Human Erythrocytes.- Free Radicals Generated in Ethanol Metabolism May Be Responsible for Tumor Promoting Effects of Ethanol.- Composition of Hepatic Lipids After Ethanol, Cod Liver Oil and Vitamin E Feeding in Rats.- Dietary Polyunsaturated Fatty Acid Promote Peroxidation and Its Possible Role in the Promotion of Cancer.- Chiral Epoxides, Their Enantioselective Reactivity Towards Nucleic Acids, and a First Outline of a Quantum Chemical Structure-Reactivity Calculation.- Comparison of 8-Hydroxydeoxyguanosine and 5-Hydroxy-Methyluracil as Products of Oxidative DNA Damage.- Modulation of Aortic Smooth Muscle Cell Prolifertion by Dinitrotoluene.- Reactive Potential of Diethylstilbestrol Reactive Metabolites Towards Cellular Nuclear Proteins: Implications for Estrogen-Induced Carcinogenesis.- Biochemical and Morphologic Response of Nasal Epithelia to Hyperoxia.- Membrane Stabilization as a Fundamental Event in the Mechanism of Chemoprotection Against Chemical Intoxication.- Biochemical Effects and Toxicity of Mitoxantrone in Cultured Heart Cells.- Evidence for the Induction of an Oxidative Stress in Rat Hepatic Mitochondria by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin (TCDD).- Antioxidation Potential of Indole Compounds — Structure Activity Studies.- Measurement of Styrene-Oxide Cysteine Adducts in Hemoglobin by Selective Catalytic Reduction.- Studies on Biochemical Determinants of Quinone-Induced Toxicity in Primary Murine Bone Marrow Stromal Cells.- Selective Alteration of Cytokeratin Intermediate Filament by Cyclosporine A Is a Lethal Toxicity in PTK2 Cell Cultures.- Rat Hepatic DNA Damage Induced by 1,2,3-Trichloropropane.- Oxidation of Reduced Porphyrins by the Mitochondrial Electron Transport Chain: Stimulation by Iron and Potential Role of Reactive Oxygen Species.- Future Research Needs for the Application of Mechanistic Data to Risk Assessment.- Contributors.