DNA Damage and Repair
Volume 2: DNA Repair in Higher Eukaryotes
Samenvatting
Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.
Specificaties
Inhoudsopgave
Biochemistry of Mammalian DNA Mismatch Repair, A-Lien Liu . Short Patch Mismatch Repair in Mammalian Cells
Paola Gallinari, Petra Nedderman, and Josef Jiricny . Role of HMG and Other Proteins in Recognition of Cisplatin DNA Damage, Paul C. Billings and Edward N. Hughes .TFIIH: A Transcription Factor Involved in DNA Repair and Cell-Cycle Regulation, Vincent Moncollin, Paul Vichi, and Jean-Marc Egly . DNA Polymerase Involvement in DNA Repair, Samuel H. Wilson and Rakesh K. Singhal . Cellular Functions of Mammalian DNA Ligases, Alan E. Tompkinson, Jingwen Chen, Jeff Besterman,
and Intisar Husain . Modulations in Chromatin Structure During DNA Damage Formation and DNA Repair, Michael J. Smerdon and Fritz Thoma . Transcriptional Responses to Damage Created by Ionizing Radiation: Molecular Sensors
Thomas W. Davis, Mark Meyers, Carmell Wilson-Van Patten, Navneet Sharda, Chin-Rang Yang, Timothy J. Kinsella, and David A. Boothman . Posttranslational Mechanisms Leading to Mammalian Gene Activation in Response to Genotoxic Stress, Yusen Liu, Myriam Gorospe, Nikki J. Holbrook, and Carl W. Anderson . Mechanisms for DNA Double-Strand Break Repair in Eukaryotes, W. Kimryn Rathmell and Gilbert Chu . Mutant Rodent Cells Defective in DNA Double-Strand Break Repair,
Penny A. Jeggo .Nucleotide Excision Repair: Its Relation to Human Disease, Larry H. Thompson . Cellular Responses to DNA Damage and the Human Chromosome Instability Syndromes, KumKum Khanna, Richard Gatti, Patrick Concannon, Corry M. R. Weemaes, Merl F.Hoekstra, Martin Lavin, and Alan D'Andrea. Genetics of Mismatch Repair, Microsatellite Instability, and Cancer, Tom Prolla, Sean Baker, and R. Michael Liskay . Mammalian Cell-Cycle Responses to DNA-Damaging Agents, Roy Rowley . Poly(ADP-Ribose) Polymerase in Response to DNA Damage, Satadal Chatterjee and Nathan A. Berger. DNA Topoisomerases in DNA Repair and DNA Damage Tolerance, John L. Nitiss . Molecular Approaches for Detecting DNA Damage, Peggy L. Olive . Radiation-Induced Damage and the Formation of Chromosomal
Aberrations, Michael N. Cornforth . Whole Organism Responses to DNA Damage: Modulation by Cytokines
of Damage Induced by Ionizing Radiation, Ruth Neta and Scott K. Durum . DNA Damage and Repair in the Clinic,
David B. Mansur and Ralph R. Weichselbaum. Index.
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