Adult Stem Cells
Samenvatting
Studies on stem cells have been attracting intense scientific and p- lic attention, not only because of controversies surrounding the use of embryonic stem cells but also because of very provocative data that have been emerging on adult stem cells. Much of the public attention and debate has been focused on the possibility that adult stem cells may be used as a substitute for human embryonic stem cells or as a justification for stopping work on them. This has somewhat dim- ished attention on very heated scientific debates that take us to the very heart of how the concept of stem cells is perceived. To this author, the latter debates have not been unlike certain philosophical debates of the last century. Since the seminal studies of Till and McCulloch in the 1960s, the popular paradigm on adult stem cells has been that lineage-restricted stem cells are derived from pluripotent stem cells very early during development. To many, and consistent with much data, the restriction to particular lineages was considered absolute. In other words, there was a sense of determinism in the stem quality of particular stem cells: once they were allocated, they were programmed to specific roles in a given tissue. Furthermore, some adult tissues were considered devoid of detectable stem cell presence or activity.
Specificaties
Inhoudsopgave
William B. Slayton and Gerald J. Spangrude
Spermatogonial Stem Cells
Dirk G. de Rooij
Stem Cells in Skeletal Muscle
Anna Polesskaya and Michael Rudnicki
Gene Therapy Using Muscle-Derived Stem Cells
Christopher Chermansky, Johnny Huard, and Michael B. Chancellor
Human Dental Pulp Stem Cells: Characterization and Developmental Potential
Stan Gronthos, Natasha Cherman, Pamela Gehron Robey, and Songtao Shi
Epithelial Stem/Progenitor Cells in Thymus Organogenesis
Hans-Reimer Rodewald
Adult Liver Stem Cells
William B. Coleman, Joe W. Grisham, and Nadia N. Malouf
Endothelial Progenitor Cells
Takayuki Asahara and Jeffrey M. Isner
Prostate Epithelial Stem Cells
Anne T. Collins and David E. Neal
Mammary Epithelial Stem Cells
Elizabeth Anderson and Robert B. Clarke
From Marrow to Brain
Josef Priller
Adult Retinal Stem Cells
Monica L. Vetter and Edward M. Levine
Multipotentiality of Iris Pigment Epithelial Cells in Vertebrate Eye
Mitsuko Kosaka, Guangwei Sun, Masatoshi Haruta, and Masayo Takahashi
Stem Cell Biology of the Inner Ear and Potential Therapeutic Applications
Thomas R. Van De Water, Ken Kojima, Ichiro Tateya, Juichi Ito, Brigitte Malgrange, Philippe P. Lefebvre, Hinrich Staecker, and Mark F. Mehler
Engineering the In Vitro Cellular Microenvironment for the Control and Manipulation of Adult Stem Cell Responses
Ali Khademhosseini and Peter W. Zandstra
Stem Cells As Common Ancestors: Somatic Cell Phylogenies From Somatic Sequence Alterations
Darryl Shibata
Index
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