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Neuroanatomy and Pathology of Sporadic Alzheimer's Disease

Specificaties
Paperback, 162 blz. | Engels
Springer International Publishing | 2015e druk, 2014
ISBN13: 9783319126784
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Springer International Publishing 2015e druk, 2014 9783319126784
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As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail

Specificaties

ISBN13:9783319126784
Taal:Engels
Bindwijze:paperback
Aantal pagina's:162
Uitgever:Springer International Publishing
Druk:2015

Inhoudsopgave

Prologue.- General Morphology of Alzheimer-associated intraneuronal pathology.- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible.- Basic organization of involved structures.- Presymptomatic stages.- General morphology of Alzheimer-associated extracellular pathology.- Symptomatic stages.- The progression of cortical lesions mimics the pattern of myelination in reverse order.- Tauopathies.- CSF biomarkers and imaging techniques.- The staging hypothesis: assumptions, challenges, potential.- Technical considerations.   

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€ 171,79
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        Neuroanatomy and Pathology of Sporadic Alzheimer's Disease