Disordered Pharmaceutical Materials

FUNDAMENTAL ASPECTS OF DISORDER
<br /> Disorder and Structure: Existence and Absence of Long Range Order
<br /> Disorder and Molecular Mobility
<br /> Disorder and Thermodynamics: Entropy and Role of Disorder in the Stability of Physical States
<br /> Chemical Disorder
<br /> Short Range Organization in Disordered Materials: Static and Dynamic Intermolecular Correlations
<br /> RELEVANCE OF DISORDER FOR PHARMACEUTICAL PRODUCTS
<br /> Disorder and Solubility
<br /> Disorder and Stability (Physical and Chemical)
<br /> Disorder and Drug Delivery
<br /> Drawback and Opportunities of Disorder
<br /> EXPERIMENTAL METHODS FOR THE INVESTIGATION OF DISORDERED MATERIALS
<br /> Investigation of Structure: Diffraction Experiments, Spectroscopies
<br /> Investigation of Mobility (Relaxations and Vibrations)
<br /> Thermodynamic and Calorimetric Investigations
<br /> Chemical Aspects
<br /> Imaging Methods
<br /> HOW DISORDERED CAN PERFECT MOLECULAR CRYSTALS BE?
<br /> Condition for the Existence of a Crystalline Order
<br /> Disordered Perfect Crystals: Substitutional, Conformational, Rotational Disorder
<br /> Crystalline Polymorphism and Disorder
<br /> Order–Disorder Phase Transitions in Molecular Crystals
<br /> Static and Dynamic Disorder in Crystals: Vibrations, Molecular Rotations, Solid Solutions
<br /> Defective Crystals
<br /> Dislocation Disorder
<br /> Microcrystalline Order
<br /> Experimental Consequences
<br /> AMORPHOUS AND GLASSY STATE
<br /> Molecular Organization in Amorphous Molecular Solids
<br /> Intermediate Range Order
<br /> Metastability and Instability of Amorphous Materials
<br /> Crystallization out of the Amorphous State;
<br /> Vitrification Condition;
<br /> Glass Transition at Tg
<br /> Molecular Mobility in the Amorphous Materials Above and Below Tg
<br /> Aging of Glasses
<br /> Glass Transition of Solutions
<br /> AMORPHOUS PHARMACEUTICALS
<br /> Preparation Techniques: Spray Drying, Freeze Drying, Extrusion, Milling
<br /> Impacts of Glass Properties on Mechanical and Surface Properties: Agglomeration, Flowability, Caking, Dissolution
<br /> Stability Issues and Possible Stability Manipulations
<br /> Amorphous Intermediates in Cocrystal Formation
<br /> MESOMORPHIC MATERIALS FOR DRUG DELIVERY
<br /> Liquid Crystals
<br /> Plastic Crystals
<br /> Macromolecular Disorder
<br /> Solubilities of Drug in Polymer
<br /> Release of a Drug from Dissolving Polymer
<br /> Gel Formation, Hydrogels
<br /> NUMERICAL MODELING OF DISORDERED PHARMACEUTICAL MATERIALS
<br /> Validity of Force Fields Used in Drug Molecular Modeling
<br /> Property–dependent Choice of Simulation Models
<br /> Modeling and Prediction of Properties
<br /> Modeling as an Help to Interpret Data
<br /> PROCESS AND DISORDER
<br /> Disorder Accidentally or Unavoidably Produced in the Course of Processing Ordered Materials
<br /> Processing of Disordered Materials
<br /> PATENTING OF DISORDERED PHARMACEUTICAL PRODUCTS
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