Multimodal Concepts for Integration of Cytotoxic Drugs

Preclinical Part.- Biological Basis of Combined Radio- and Chemotherapy.- Combinations of Antimetabolites and Ionizing Radiation.- Combinations of Taxanes and Ionizing Radiation.- Combinations of Topoisomerase Inhibitors and Ionizing Radiation.- Combinations of Hypoxia-Targeting Compounds and Radiation-Activated Prodrugs with Ionizing Radiation.- Combinations of Platinum Compounds and Ionizing Radiation.- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Angiogenesis Inhibitors.- Combinations of Cytotoxic Drugs, Ionizing Radiation and EGFR Inhibitors.- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors.- Combinations of Ionizing Radiation and Other Sensitizing Agents.- Radiotherapy and Tumor-Targeted Drug Delivery.- Clinical Part.- Applications in Malignant Brain Tumors.- Applications in Head and Neck Cancer.- Applications in Esophageal and Gastric Cancer.- Novel Chemoradiation in Localized Pancreatic Cancer: Clinical Studies.- Applications in Lung Cancer.- Integration of Radiation Therapy and Systemic Therapy for Breast Cancer.- Applications in Rectal and Anal Cancer.- Concomitant Radiation and Chemotherapy in Muscle-Invasive Bladder Cancer.- Applications to Gynecological Cancers.- Early and Late Treatment-Induced Toxicity.- Feasibility of Combined Chemo- and Radiation Treatment in Elderly/Comorbid Patients.