Transgenic Models in Pharmacology

Preface.- Part 1: Transgenic Techniques.-1. Novel mouse models in biomedical research: The power of dissecting pathways by quantitative control of gene activities.- Part 2: Molecular Systems.- 2. Adrenergic System. 3. Muscarinic Acetylcholine Receptor Knockout Mice. 4. Mouse Models of NO/ Natriuretic Peptide/ cGMP Kinase Signaling. 5. Transgenic Models for the Study of Protein Kinase A-regulated Signal Transduction. 6. G-Protein-Mediated Signalling Pathways. 7. Analysis of Integrin Function by Gene Targeting in Mice. Part 3: Nervous System.- 8. Transgenic Mouse Models in the Analysis of Neurotransmitter Release Mechanisms. 9. Analysis of GABA receptor assembly and function in targeted mutant mice. 10. Neurotrophic Factors. 11.Genetic Analysis of the Endogenous Opioid System.- Part 4: Cardiovascular System.- 12. Transgenic Mouse Models of Cardiovascular Function and Disease. 13. Renin-Angiontensin-System/Blood Pressure Control. 14. Lipoprotein Transport.- Part 5: Immunology/Hematology/Inflammation.- 15. Transgenic Animals of Enzymes and Receptors in Prostanoid Synthesis and Actions; Phenotypes and Implications in Drug Development. 16. Coagulation and Fibrinolysis in Genetic Modified Mice. 17. Transgenic Animals in Primary Hemostasis and Thrombosis. 18. Chemokine Receptors.- Part 6: Endocrinology.- 19. Steroid Receptors. 20. Reproductive System.- Part 7: Toxicology.- 21. Understanding Molecular Mechanism of Toxicity and Carcinogenicity Using Gene Knockout and Transgenic Mouse Models.