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Interleukin-10 in Health and Disease

Specificaties
Paperback, blz. | Engels
Springer Berlin Heidelberg | e druk, 2016
ISBN13: 9783662524053
Rubricering
Juridisch :
Springer Berlin Heidelberg e druk, 2016 9783662524053
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.

Specificaties

ISBN13:9783662524053
Taal:Engels
Bindwijze:paperback
Uitgever:Springer Berlin Heidelberg

Inhoudsopgave

<p>IL-10 in humans: lessons from the gut, IL-10/IL-10 receptor deficiencies, and IL-10 polymorphisms. </p><p>Karin R. Engelhardt and Bodo Grimbacher</p><p>Control of intestinal inflammation by interleukin-10.</p><p>Abhisake Kole and Kevin J. Maloy</p><p>Tr1 cells and the counter-regulation of immunity: natural mechanisms and therapeutic applications.</p><p>Maria Grazia Roncarolo, Silvia Gregori, Rosa Bacchetta and Manuela Battaglia.</p><p>Interleukin-10-producing B cells and the regulation of immunity.</p><p>Ellen Hilgenberg, Ping Shen, Van Duc Dang, Stefanie Ries, Imme Sakwa and Simon Fillatreau.</p><p>Pathogen Manipulation of cIL-10 Signaling Pathways: Opportunities for Vaccine Development?</p><p>Meghan K. Eberhardt and Peter A. Barry</p><p>IL-10: achieving balance during persistent viral infection.</p><p>Cherie T. Ng and Michael B.A. Oldstone</p><p>The role of microRNAs in the control and mechanism of action of IL-10.</p><p>Susan R. Quinn, Luke A. O’Neill</p><p>The regulation of IL-10 expression.</p><p>Leona Gabryšová, Ashleigh Howes, Margarida Saraiva and Anne O’Garra</p><p>The Molecular Basis of IL-10 Function:  From Receptor Structure to the Onset of Signaling.</p><p>Mark R. Walter</p><p>Role of IL-22 in microbial host defense</p><p>Celine Eidenschenk, Sascha Rutz, Oliver Liesenfeld, Wenjun Ouyang</p>

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