Lipid-Lowering Therapy and Progression of Coronary Atherosclerosis

One: Mechanisms of progression and regression.- 1. Role of lipoproteins in progression of coronary arteriosclerosis.- 2. Pathophysiological basis for lipid intervention trials.- Two: Methodological aspects of angiographic trials.- 3. The use of metabolic measurements in angiographic regression trials.- 4. Quality control in quantitative coronary arteriography.- 5. Is there a place for visual assessment?.- 6. Angiographic endpoints in progression trials.- Three: Angiographic lipid lowering clinical trials.- 7.The Cholesterol Lowering Atherosclerosis Study (CLAS).- 8. Clinical efficacy and safety of pravastatin treatment in symptomatic patients — the REGRESS trial.- 9. Familial Atherosclerosis Treatment Study.- 10. Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC 1): a summary.- 11. The Multicenter Anti-Atheroma Study (MAAS).- 12. Lessons from the Monitored Atherosclerosis Regression Study (MARS) and beyond: atherosclerosis progression/regression responses to therapy depend on lesion size and composition.- 13. The St Thomas’ Atherosclerosis Regression Study and an appraisal of its potential limitations.- 14. Effects of the lipid intervention in the Stanford Coronary Risk Intervention Project.- 15. Canadian coronary atherosclerosis study on the effect of lovastatin on the progression of coronary artery disease (CCAIT): why are results different?.- 16. Impact upon angiographic disease progression following step drug therapy in normolipidaemic patients: results of the Harvard Atherosclerosis Reversibility Project (HARP).- 17. Effect of aggressive versus conventional lipid-lowering treatment on coronary and peripheral atherosclerosis: design and baseline characteristics of the LDL-Apheresis Atherosclerosis Regression Study (LAARS).- 18. The NHLBI Post-Coronary Artery Bypass Graft Clinical Trial (Post-CABG): angiographic outcomes.- Epilogue.